TIC-TOC: PANDAS syndrome (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection) and psychiatric pathology in children and adolescents

Hilario Blasco-Fontecilla, Victor del Rio-Peña, Ping Wang, Chao Li, Marina Martin-Moratinos, Marcos Bella-Fernández, Trastorno por tics y trastorno obsesivo compulsivo: Trastornos neuropsiquiátricos pediátricos autoinmunes asociados a infecciones por estreptococos (PANDAS) y enfermedades psiquiátricas en niños y adolescentes, Psiquiatría Biológica, Volume 31, Supplement 1, 2024,100554, ISSN 1134-5934,https://doi.org/10.1016/j.psiq.2024.100554.

• Study Overview: Compared 801 children with and without ASLO positivity (Antistreptolysin O, a marker of past strep infection).
• ASLO-positive kids are 7x more likely to have tics & OCD.
• More ER visits and higher trauma/fracture rates.
• No link to ADHD or academic performance.