Immuno-moodulin: A new anxiogenic factor produced by Annexin-A1 transgenic autoimmune-prone T cells
Patients with obsessive compulsive disorder (OCD) have increased levels of Immuno-moodulin (Imood), a protein in their lymphocytes, a type of immune cell.
Anxious mice returned to normal in a couple of days after being given an antibody that blocked Imood. Twenty-three people with OCD and twenty healthy people without OCD were tested; Imood expression was about six times higher in those with OCD. Additional research indicates the same protein, Immod, is elevated in ADHD.
“There is mounting evidence that the immune system plays an important role in mental disorders. People with auto-immune diseases are known to have higher than average rates of mental health disorders such as anxiety, depression and OCD. Our findings overturn a lot of the conventional thinking about mental health disorders being solely caused by the central nervous system.”
Professor ulvio D’Acquisto, professor of immunology at the University of Roehampton and honorary professor of Immunopharmacology at Queen Mary University of London.
15 comments to Antibodies for OCD
Sarah edmendsMay 1, 2020
My daughter suffers from
Ocd that has taken over her life at the moment. She is trying ERP which is extremely hard and stressful . I just wondered about these antibody trials and when
More news would become apparent on whether they work and if so when it would become a available?
Gabriella TrueMay 1, 2020
Sent you an email.
JanMay 21, 2020
I have the same question as Sarah. When would this anybody treatment become available and where?
Gabriella TrueMay 27, 2020
This is really just the beginning of this information so there is no way to know if or when a test much less treatment will be available.
LeeJune 28, 2020
A close friend of mine has been suffering from OCD for 40-plus years, having tried everything from every med recommended for OCD, along with off-label use of many other meds, to CBT multiple times, to TMS for OCD. OCD is primarily intrusive thinking and my friend is beyond discouraged, not knowing what else to try. Do you have any idea of when trials of this antibody may start or any other information? Any info you could share via email would be so helpful. My dear friend is exhausted and losing hope. Thank you so very much!
Gabriella TrueJuly 7, 2020
I am sorry. We really don’t know. This is very new science and science moves glacially slow. We are not affiliated with the researchers on this study. You could try emailing them directly.
harpreet SinghAugust 17, 2020
So How Could I know that the trails have been started to develop antibodies .
I want to join that if possible .
Gabriella TrueAugust 27, 2020
You would have to contact the authors of the study directly.
amirJune 3, 2020
Hi, my name is Amir. I have been suffering from ocd for about 15 years. I followed all the medications, such as Biohoven\’s glutamate and artificial intelligence, and I\’m still undergoing homeopathy.That didn\’t have much effect. But I was hopeful to see this antibody called Imood. I published my email. Let me know.
amirJune 3, 2020
thank\’s so much
MatthewJanuary 6, 2021
I have ocd and am desperate for a treatment that works I currently take cbd and a bit of weed as its the only thing that reduces my worryes and obsessions I am also involved in a study to do with stimulating the brain in targeted areas witch are very shot lived but has altered my obsessions we all need this so badly I already suffer from a bad spine I also have adhd an Asperger’s life is grim but this is giving me hope any idear when trials will start as I’ll take anything at this point I don’t won’t much in life but to remove ocd even if I still have adhd and Asperger’s let’s hope this works out I would be forever thankful
Gabriella TrueJanuary 6, 2021
Have you ever spoken to a doctor about PANS PANDAS? Some patients with OCD, aspergers and adhd A actually have PP.
KirkMarch 14, 2021
My daughter also is suffering with OCD, Anxiety and Depression and is Autoimmune thryoid with Hashimotos. She has been in treatment for over a year for all of these and nothing has helped. Is there any way to be part of a trial for this potential treatment or anything that can be done naturally to help with this antibody? Would so much love to give her some/relief. Everything to this point almost seems to be making her more depressed/anxious.
Gabriella TrueMarch 14, 2021
Hi, We are only sharing information on the study after we read it. You would have to talk to the study authors directly to see what their next steps are. Usually, the study has ways to contact at least one of the authors directly. Often takes time for them to respond so make sure to follow up if you don’t hear from them.