Sammi’s Remarkable Comeback: From Struggle to Strength!
In late November of 2023, we noticed that our daughter, Sammi, had a limp. She had fallen and said her knee hurt. The next week, she began acting very tired...
October 2, 2024
The Cost of Inaction –
What is the cost of not treating PANS/ PANDAS promptly & appropriately? We recently sat down with Susan Swedo, MD, to discuss a critical topic: the cost of inaction when...
October 2, 2024
Cincinnati Region ChitChat Meetup
Mason, Ohio ChitChat - Wednesday, November 6th - 7:00 PM...
IVIG response in pediatric acute-onset neuropsychiatric syndrome correlates with reduction in pro-inflammatory monocytes and neuropsychiatric measures
Melamed, Isaac, et al.“IVIG Response in Pediatric Acute-onset Neuropsychiatric Syndrome Correlates with Reduction in Pro-inflammatory Monocytes and Neuropsychiatric Measures.”Frontiers in Immunology, vol. 15, 2024, p. 1383973, https://doi.org/10.3389/fimmu.2024.1383973. Accessed 3 Oct. 2024.
- Study aimed to investigate the pro-inflammatory state in PANS patients before and after IVIG treatment.
- Ten male PANS patients (ages 6–16) received six IVIG infusions over 3 weeks.
- Blood samples and psychiatric assessments were taken before treatment and at follow-up points (4 and 11 weeks post-treatment).
- Myeloid cell activation was analyzed using flow cytometry.* Significant improvement in all psychiatric assessments and parent-reported outcomes (CY-BOCS, YGTSS, and PANS rating scales; all p<0.001).
- Pro-inflammatory monocytes and dendritic cells significantly decreased after IVIG.
- Reduction in pro-inflammatory monocytes was observed both proportionally and in absolute numbers.
October 1, 2024
Legislative Action: Information for Legislators Toolkit
Download Toolkit Legislative Action: Information for Legislators Toolkit Download ASPIRE’s PANS/PANDAS Legislative Action: Information for Legislators Toolkit. This Legislative Toolkit...
October 1, 2024
California PANS PANDAS Updates
California Legislative Action Please follow this page and ASPIRE’s social media for updates – Facebook and Instagram. Please contact CALPANS with questions regarding California legislative...
October 1, 2024
PANS PANDAS School In-Service Lecture – Resources
Thank you for having ASPIRE come talk to your school about PANS PANDAS. Please take a minute to fill out the survey below. School Resources for PANS PANDAS PANS @School...
September 30, 2024
World PANS PANDAS Awareness Day #LightUp4PANS
Volunteers Needed: We need volunteers to reach out to their municipalities to request that they light up monuments, like the state house, bridges, monuments, etc., be lit up on October 9th,...
Bennett’s PANS PANDAS Story
Bennett was a typically developing 7-year-old boy when he started second grade, the first year back to school full time after COVID-19, without masks. That December, he came down...
September 22, 2024
South & North Carolina Zoom ChitChat
SC/NC Zoom ChitChat - Sunday, October 27, 2024 - 8:00 PM EDT...
September 22, 2024
Midwest Region Zoom ChitChat
Midwest Regional Zoom ChitChat Wednesday, October 9, 2024 - 12:00 PM...
Don’t Give Up – Skylar’s PANS/PANDAS Story
Hi! My name is Skylar, and I was diagnosed with PANS in October 2023 after struggling with it for around 10 years. I was 7 or 8 years old...