PANS Australia Conference
February 23, 2021
PANS Australia Conference

The conference is for parents and professionals and is completely online so available world-wide.  It will be recorded and available for viewing for ticket holders for a period of time after the...

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Perfectionism and Difficulty Controlling Thoughts Bridge Eating Disorder and Obsessive-Compulsive Disorder Symptoms: A Network Analysis

Irina A. Vanzhula, Shruti S. Kinkel-Ram, Cheri A. Levinson. Perfectionism and Difficulty Controlling Thoughts Bridge Eating Disorder and Obsessive-Compulsive Disorder Symptoms: A Network Analysis. Journal of Affective Disorders. Volume 283, 2021,p 302-309, DOI: 10.1016/j.jad.2021.01.083.

Highlights

  • Difficulties controlling intrusive thoughts is a common symptom between eating disorders and OCD
  • Perfectionism symptoms bridge eating disorders and OCD
  • Restriction links to checking compulsions and rigidity
  • Binge eating links to hoarding symptoms

Conclusions
The presence of intrusive cognitions and maladaptive perfectionism may contribute to the maintenance of co-occurring ED and OCD symptoms. These findings begin to delineate specific pathways among OCD and ED symptoms, which can be used in the development of interventions to disrupt connections among these disorders.

 

Patients with abrupt early-onset OCD due to PANS tolerate lower doses of antidepressants and antipsychotics

Margo Thienemann, Michelle Park, Avis Chan, Jennifer Frankovich. Patients with abrupt early-onset OCD due to PANS tolerate lower doses of antidepressants and antipsychotics. Journal of Psychiatric Research, Vol 135, 2021, PP 270-278. DOI: 10.1016/j.jpsychires.2021.01.022.

  • More than half of patients with PANS require psychotropic medication.
  • Side effects requiring a therapy change are common.
  • Drug doses at which side effects occur are usually less than recommended.
  • Clinicians should start with lower doses of psychotropics in PANS patients.

“Antidepressants’ most common side effects were anxiety, agitation, aggression, and akathisia. Antipsychotics’ most common side effects were dystonia, aggression, self-injurious behavior, and movement abnormality. Side effects were common at doses lower than the suggested starting doses for these medications. Patients tolerated antidepressants and antipsychotics when doses were low.”

Tetracyclines for COVID-19 Neurological and Neuropsychiatric Manifestations to treat Neuroinflammation

Tetracyclines for COVID-19 Neurological and Neuropsychiatric Manifestations to treat Neuroinflammation

Highlights

  • Neuropsychiatric symptoms were reported during COVID-19.
  • Coronaviruses have neuroinvasive potential and induce a potent neuroinflammatory response.
  • Tetracyclines can counteract neuroinflammation caused by neurotrophic viruses.
  • Tetracyclines interact with viral proteins presenting antiviral effects.
  • Tetracyclines represent a potential treatment for COVID-19 neuropsychiatric symptoms.

Chaves Filho, A.J.M., Gonçalves, F., Mottin, M. et al. Repurposing of Tetracyclines for COVID-19 Neurological and Neuropsychiatric Manifestations: A Valid Option to Control SARS-CoV-2-Associated Neuroinflammation?. J Neuroimmune Pharmacol (2021). https://doi.org/10.1007/s11481-021-09986-3