PANS has multiple etiologies and disease mechanisms. PANDAS is a subset of PANS that requires a temporal relationship with Group A strep.
What Causes PANS?
PANS can be triggered by infections, metabolic disturbances, neurological issues, psychosocial stress, and other inflammatory reactions. It is a clinical condition defined by the sudden encephalitic-like onset of obsessive-compulsive symptoms and/or severe eating restrictions and at least two concurrent cognitive, behavioral, or neurological symptoms.
Post-infectious Autoimmunity and/or Neuroinflammation are found in more than 80% of PANS cases.
PANDAS is triggered specifically by Streptococcus Pyogenes, better known as Group A Strep (GAS). PANDAS symptoms may start during or right after an active infection, but they can start a month or two after the GAS infection has resolved. Not all patients with GAS have acute pharyngitis. GAS is not limited to the throat; infections may be found in the perianal area, the skin, or the sinuses. PANS is the umbrella syndrome. PANDAS is a disorder that falls under the PANS umbrells. See the PANS PANDAS Flow Chart below.
Researchers are working to understand how GAS and other triggers result in neuropsychiatric disorders. Current research is focused on understanding the relationships among immune system function, the blood-brain barrier, and genetics.
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Learn about other families whose lives have been affected by PANS/PANDAS — and be inspired to share your own.
The Happiest Place on Earth
They say that when your child has PANS/PANDAS that you often remember the exact moment something changed. For our oldest son, Neely, that “moment of change” happened in front of Dumbo in Fantasyland, he was six (first grade). As I stood there with our two-year-old in the stroller and crying and pregnant with our third […]