Understanding the diagnostic process and criteria is important for medical providers, patients, and families.

PANS PANDAS Diagnostic Criteria

PANS and PANDAS are a clinical diagnosis and diagnosis of exclusion; PANS is the umbrella term. Diagnosis is based on an analysis of the child’s medical history, current symptoms, and physical examination. Lab work and additional testing can be ordered to identify an infectious trigger, rule out other diagnoses, and inform treatment plans. A diagnosis of PANS PANDAS is never based on one or two test results. The disease course is typically relapsing and remitting but can become chronic/static. 

Learn more about PANS PANDAS Symptoms.


Pediatric Acute-onset Neuropsychiatric Syndrome
  • Abrupt, acute onset of obsessive-compulsive disorder or severely restricted food intake
  • Concurrent presence of additional behavioral or neurological symptoms with similarly acute onset and severity from at least 2 of the following categories:
    1. Anxiety, Separation Anxiety
    2. Emotional Lability and/or Depression
    3. Irritability, Aggression, and/or Severe Oppositional Behaviors
    4. Behavioral (Developmental) Regression
    5. Sudden Deterioration in School Performance
    6. Motor or Sensory Abnormalities
    7. Somatic Signs and Symptoms, including Sleep Disturbances, Enuresis, or Urinary Frequency
  • Symptoms are not better explained by a known neurologic or medical disorder
  • Age requirement – None

Consensus Statement on Diagnosing PANS and PANDAS –Clinical Evaluation of Youth with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS): Recommendations from the 2013 PANS Consensus Conference. Chang, MD et al. (JCAP, Vol 25, No 1, 2015 Mary Ann Liebert, Inc.)


Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections
  • Presence of OCD and/or tics, particularly multiple, complex or unusual tics
  • Age Requirement (Symptoms of the disorder first become evident between 3 years of age and puberty)
  • Acute onset and episodic (relapsing-remitting) course
  • Association with Neurological Abnormalities

Note: Comorbid neuropsychiatric symptoms are universally present in PANDAS, similar to the diagnostic criteria for PANS with similarly abrupt onset/exacerbation as the primary symptoms of PANDAS. In particular, the somatic symptoms such as urinary frequency, mydriasis, and insomnia, help differentiate PANDAS from Tourette syndrome or non-PANDAS OCD.

Diagnostic Process

Review Symptoms, Medical History, Physical Exam

Draw Labs to Understand Infections and Immune System Function

Perform Imaging or Other Testing to Rule Out Other Conditions

1. Review Symptoms, Medical History, Physical Exam

If a parent or provider suspects PANS/PANDAS as a cause of neuropsychiatric symptoms, the first step in Diagnosing PANS and PANDAS is to perform a complete medical and psychiatric history, and medical exam. Take care to document past infections and the onset of neuropsychiatric symptoms. Family history reveals high rates of OCD, Sydenham Chorea, Rheumatic Fever, and Autoimmune disease in patients’ parents and grandparents.

Parent Tip: If you think your child might have PANS/PANDAS, take time before your medical appointment to compile a detailed medical history with all infections and symptoms.  There are PANS/PANDAS Symptom Tracking Tools to track onset of symptoms, severity of symptoms, and secondary flares. ASPIRE has also created a guide and tools Your First Appointment.

Physical Signs: Patients can have many physical signs of illness that can influence diagnosis and treatment protocols.

  • Eyes can be dilated.
  • Patients can have vision issues, including distortions or hallucinations.
  • Rheumatologic workups reveal that 80% of PANS patients have arthralgias, myalgias, and other evidence of inflamed joints & muscles.
  • Patients may have “Piano Fingers” movements, which are different from the more significant movements seen in Sydenham Chorea.
  • There are physical signs of strep: Peeling skin on hands or feet, red anal ring, strawberry tongue.
  • There are physical signs of other infections: warts, molluscum, ringworm, ridged nails, etc.
  • Trichotillomania (hair pulling) or Skin Picking

2. Lab Work

After reviewing the child’s history, the next step in diagnosing PANS and PANDAS is utilizing lab work to identify inciting infections.

 “Careful consideration of possible inciting infections is important at both the initial onset and symptom exacerbations of PANS or PANDAS. A detailed history of exposures to contagious illnesses should be obtained, with cognizance of their associated incubation periods. Physical examination should focus on infection at any site, including dental, pharyngeal, lymphatic, and perianal and all other skin sites.” Reference: Clinical Management of Pediatric Acute-Onset Neuropsychiatric Syndrome: Part III—Treatment and Prevention of Infections – JCAP Vol27, #7, 2017 – Cooperstock, MD, MPH, Swedo, MD, Pasternack, MD, Murphy, MD

Basic labs should include:
  • Strep throat culture, 48-hour culture and/or perianal culture
  • Bacteria & Virus Blood Work:
    • Anti-Streptolysin (ASO)
    • Anti DNase B
    • Streptozyme
    • Mycoplasma Pneumoniae
    • Pneumococcal Antibody
    • Epstein Barr Virus Panel
    • Coxsackie A & B Titers
    • Lyme Disease and co-infections: Lyme Western Blot & Elisa, Babesia microti & duncani, Bartonella, B. Miyamotoi, Ehrlichia, Anaplasma
    • HHV-6
  • Immune System & Autoimmune Testing:
    • IgE Level
    • IgA, IgG, IgM
    • IgG (subclass 1, 2, 3, 4)
    • Streptococcus Pneumoniae Serotypes
    • CBC
    • ANA
Further Testing:
  • Ferritin
  • Serum Copper
  • B-12
  • Vitamin D
  • Plasma Amino Acids
  • Organic Acids Test
  • Stool Testing
  • Free T3 & T4 and TSH (Thyroid)
Cunningham Panel:
  • Note: this test is not required for diagnosis and not necessary for many PANS PANDAS patients. Please refer to the PPN Treatment Guidelines for more information.
  • autoimmune autoantibody levels: Dopamine D1 receptor, Dopamine D2L receptor, Lysoganglioside GM1, Tubulin, & CamKinase

3. Imaging or Other Testing to Rule Out Other Conditions

PANS/PANDAS is a diagnosis of exclusion, meaning symptoms cannot be better explained by another diagnosis.  Depending on a child’s presentation and the severity of symptoms, further testing is often advised.  Other testing might include:

  • CSF
  • EKG/Echo
  • Polysomnography

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