Repeated Flares & Baseline

Do patients go back to baseline between flares/exacerbations?

Not always. Some symptoms can remit fully while others are reduced but not back to baseline.

PANS PANDAS Symptom Severity

Source: NIMH Information About PANS/PANDAS https://www.nimh.nih.gov/research/research-conducted-at-nimh/research-areas/clinics-and-labs/sbp/information-about-pans-pandas.shtml

Note: PANS has multiple triggers, not just strep. This chart uses strep as an example incitatory trigger but please note that any PANS trigger could replace strep on this chart. Learn more about the definition of PANS/PANDAS.

PANS symptoms can relapse and remit. In between flares, symptoms do not always go back to baseline. Unfortunately, in some cases, subsequent flares can be more severe with a longer duration; symptoms move further away from baseline and can become chronically debilitating.

PANS symptoms can remit completely, especially if treated quickly and thoroughly. Treatment plans should not only include treatments to clear the current flare but also address symptoms that have not returned to baseline. Ultimately the goal is to relieve symptoms and prevent symptoms from becoming chronically debilitating. See Treatments.