If the embedded video link does not play on this page, please watch directly on YouTube. Symposiums ASPIRE was invited by the Associazione Genitori Pans Pandas Bge Organizzazione...
There are invaluable resources to help clinicians and providers recognize PANS symptoms, do a workup to inform a possible diagnosis and create a treatment plan. ASPIRE has assembled the information below to provide a place to start. Additionally, there are resources throughout the website, including resource articles at the bottom of this page.
PANS Diagnostic Criteria
PANS Consensus Statement on Diagnosing PANS and PANDAS –Clinical Evaluation of Youth with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS): Recommendations from the 2013 PANS Consensus Conference. Chang, MD et al (JCAP, Vol 25, No 1, 2015 Mary Ann Liebert, Inc.)
- Abrupt, acute onset of obsessive-compulsive disorder or severely restricted food intake
- Concurrent presence of additional behavioral or neurological symptoms with similarly acute onset and severity from at least 2 of the following categories:
- Emotional Lability and/or Depression
- Irritability, Aggression, and/or Severe Oppositional Behaviors
- Behavioral (Developmental) Regression
- Sudden Deterioration in School Performance
- Motor or Sensory Abnormalities
- Somatic Signs and Symptoms, including Sleep Disturbances, Enuresis, or Urinary Frequency
- Symptoms are not better explained by a known neurologic or medical disorder
- Age requirement – None
The Diagnostic Process
- Step 1: Review Symptoms, Medical History, Physical Exam
- Step 2: Draw Labs to Understand Infections and Immune System Function
- Step 3: Perform Imaging or Other Testing to Rule Out Other Conditions
The PANDAS Physicians Network (PPN) flowcharts for diagnosis and treatment will help clinicians evaluate their patients and determine the best course of treatment. Guidelines and workflows were approved by practitioners of the PANDAS Physicians Network Scientific Advisory Board. More detailed resources are available at www.pandasppn.org. Diagnosing and treating should be done by a licensed healthcare provider.
Primary care providers play important, ongoing roles in the diagnosis, treatment, and recovery of children with PANS/PANDAS. Children with a moderate or severe/life-threatening onset or a complex presentation may require treatment by an experienced multi-disciplinary team of specialists or a PANS/PANDAS specialist. Additional resources can be found at
PANS PANDAS Treatment Guidelines
PANS treatment utilizes three complementary modes of interventions to treat the patient completely. Three-pronged treatment protocols are dependent on disease trajectory, symptoms, and severity as well as lab work and patient history.
- Provide Symptomatic Relief
- Treat Postinfectious Autoimmunity and/or Neuroinflammation
- Treat Source of Infection
The PANDAS Physicians Network (PPN) flowcharts for diagnosis and treatment will help clinicians evaluate their patients and determine the best course of treatment. The diagnostic flowchart and treatment guidelines include a detailed process provided for determining the appropriate diagnosis and symptom severity-based treatment protocols for mild, moderate, and severe/extreme cases.
ASPIRE PANS PANDAS Toolkits & Resources for Providers
PANS PANDAS Clinician Toolkit
There are invaluable resources to help clinicians learn how to recognize PANS PANDAS symptoms, do a workup to inform a possible diagnosis, and create a treatment plan. ASPIRE has assembled this one-page Clinician Toolkit but there are many resources throughout the website, and we are always adding more. So, check the website often.
Click the button below to download the twelve-page information packet Provider Information on PANS PANDAS, including Symptoms, Diagnosis, and Treatment.
PANS PANDAS Guidelines for Children with Autism
ASPIRE’S Professional Advisory Board Toolkit:
ASPIRE’S Professional Advisory Board Toolkit:
PANS/PANDAS Symptoms Tracking & Rating Tools
PANS is a clinical condition identified by an abrupt onset of a specific cluster of symptoms as a result of a variety of etiologies and disease mechanisms. Therefore, tracking symptoms, onset, severity, and duration is a critical part of making a clinical diagnosis and forming treatment plans. There are two useful PANS Symptom Rating Scale tools.
10 THINGS You Should Know
About PANS PANDAS
Provider Resources: Articles, Brochures, Webinars
Clinician Resources: Articles, Brochures, Webinars
You can scroll through the pages of the Clinician Resources below. However, clicking on the link to the main Clinician Resources page is easier. Otherwise, you will be redirected to the top of this page each time you scroll to a secondary page in the resources.
The Comprehensive Physicians’ Guide to the Management of PANS and PANDAS: An Evidence-Based Approach to Diagnosis, Testing, and Effective Treatment Hardcover
An evidence-based guide for doctors diagnosing, testing, and treating children with PANDAS (Pediatric Autoimmune Neuropsychiatric Disorder Associated with Strep...
CE Course: Inflammatory Brain Disorders in Psy Practice: Pediatric Acute-Onset Neuropsychiatric Syndrome
Inflammatory Brain Disorders in Psychological Practice: A Focus on Pediatric Acute-Onset Neuropsychiatric Syndrome Sunday, May 7th, 10:00 AM – 12:30 PM Pacific Time Presented by Zoe...
ASPIRE’S Professional Advisory Board publishes Testing & Antibiotic Usage for GAS in PANS & PANDAS The section below provides only a brief overview of the Professional Advisory Board...
Speaker: Vicki Kobliner, MS, RDN Webinar: Nutritional Interventions in PANS/PANDAS Watch Recorded Webinar: Register to View Materials from Webinar PDF File: Phytonutrient Spectrum Checklist...
Demystifying PANS/PANDAS is a unique and long overdue resource in the field of pediatric neurobehavioral health, providing a comprehensive overview of the “three-pronged approach” to assessment...
Dr. Swedo will present an Overview of PANDAS, PANS, and Childhood-onset OCD at two Blank Children’s Hospital Events Presented by Susan E. Swedo, M.D. NIH Scientist Emerita Chief Science...
Webinar – Susan Swedo, MD – PANS and PANDAS Recognition, Diagnosis and Treatment of Acute-onset Neuropsychiatric Symptoms
Lecturer: Susan Swedo, MD Webinar: PANS and PANDAS Recognition, Diagnosis and Treatment of Acute-onset Neuropsychiatric Symptoms Date/Time: Thursday, March 24 To Watch Webinar: Please fill out the...