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Rare Disease Day 2021
January 21, 2021
Rare Disease Day 2021

Whether you think PANS/PANDAS is a Rare Disease or actually just rarely diagnosed, it is a day to educate people about PANS/PANDAS. The main objective of Rare Disease Day is to raise awareness...

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Genes, Cells, and Neural Circuits Relevant to OCD and Autism Spectrum Disorder

Editor’s Note:
Genes, Cells, and Neural Circuits Relevant to OCD and Autism Spectrum Disorder
Ned H. Kalin, M.D.
Published Online:1 Jan 2021 DOI 10.1176/appi.ajp.2020.20111605

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“These cross-species translational data are potentially exciting and serve to focus the search for the pathophysiology of PANDAS toward a specific class of inter-neurons within the striatum that are known to fine tune and regulate striatal output via their influences on the abundant medium spiny GABAergic neurons that project to effector sites. Because of the similarities between PANDAS and bonafide OCD, these studies raise the possibility that striatal cholinergic interneurons are mechanistically involved in the pathophysiology of childhood OCD. In his editorial (9), Dr. Steve Hyman from Harvard University critically appraises this study and suggests that, in addition to the mechanism suggested by the findings in this article, other immune-related molecular pathways may also be important.”

Predictors and Prospective Course of PANS: A Pilot Study Using Electronic Platforms for Data Collection

Predictors and Prospective Course of PANS: A Pilot Study Using Electronic Platforms for Data Collection

Conclusion: Our study highlights the utility of electronic methods for tracking longitudinal symptoms in children with PANS and suggests that particular baseline characteristics (e.g., delay in identification and treatment of PANS, greater caregiver burden) may be indicative of a differential trajectory of PANS course, with more severe symptoms over the short term. clinicaltrials.gov NCT04382716.

Elizabeth C. Harris, Christine A. Conelea, Michael T. Shyne, and Gail A. Bernstein.Journal of Child and Adolescent Psychopharmacology. http://doi.org/10.1089/cap.2020.0124
2020 Year in Review
December 28, 2020
2020 Year in Review

Despite the challenges of 2020, we are proud to report that the ASPIRE community continues to grow in size, support, and strength. We are grateful to all of you for your contributions: the...

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