The question of PANDAS in adults

Sara M Bodner, Syed A Morshed, Bradley S Peterson, The question of PANDAS in adults, Biological Psychiatry, Volume 49, Issue 9, 2001, Pages 807-810, ISSN 0006-3223,

We describe an adult with onset of obsessive–compulsive disorder at 25 years of age after a severe antibiotic-responsive pharyngitis. He was evaluated with multiple psychiatric rating scales for obsessive–compulsive disorder and Tourette’s syndrome, as well as with serologic assays and radiologic studies.

Results: In all respects except age our patient fulfilled established criteria for PANDAS. Assays for antibodies to group A β-hematolytic streptococci, serum D8,17 lymphocytes, antistriatal (neuronal) antibodies, and anticytoskeletal antibodies all supported the hypothesis that a poststreptococcal process was active. Magnetic resonance imaging was abnormal and is described.

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