Neuropsychiatric consequences of childhood group A streptococcal infection: A systematic review of preclinical models

Santiago Mora, Elena Martín-González, Pilar Flores, Margarita Moreno
Brain, Behavior, and Immunity-2019

Preclinical Animal Models are advancing our knowledge of Post-Infectious BGE

• Preclinical GAS exposure induced behavioural abnormalities in different paradigms
• Alterations induced by preclinical GAS exposure resemble those by LPS and Poly I:C.
• Preclinical GAS exposure increase vulnerability to neuropsychiatric disorders.
• Preclinical GAS exposure is a valid model for studying streptococcal consequences.