Metabolomic Characterization of Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS)
F Murgia, A Gagliana, MG Tanca, N Or-Geva, A Hendren, S Carucci, M Pintor, F Cera, F Cossu, S Sotgiu, L Atzori, A Zuddas. Metabolomic Characterization of Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS). Frontiers in Neuroscience. Vol 15. 2021. DOI: 10.3389/fnins.2021.645267
- Found unique plasma metabolic profile in PANS patients that is significantly different from healthy children
- Suggests involvement of specific patterns of neurotransmission (tryptophan, glycine, histamine/histidine)
- Suggests a general state of neuroinflammation and oxidative stress (glutamine, 2-Hydroxybutyrate, and tryptophan-kynurenine pathway) in the disorder.
- Offers new insights into biological mechanisms underpinning the disorder and supports research of other potential biomarkers implicated in PANS.