Menendez CM, Zuccolo J, Swedo SE, Reim S, Richmand B, Ben-Pazi H, Kovoor A, Cunningham MW. Dopamine receptor autoantibody signaling in infectious sequelae differentiates movement versus neuropsychiatric disorders. JCI Insight. 2024 Nov 8;9(21):e164762. doi: 10.1172/jci.insight.164762. PMID: 39325550; PMCID: PMC11601707.
- Autoantibodies (AAbs) to different dopamine receptors can differentiate movement disorders and neuropsychiatric disorders following Group A streptococcal (GAS) infection. GAS-induced cross-reactive AAbs promote autoimmune encephalitis of the basal ganglia, a region with high dopamine receptor density.
- The research provides insights into the mechanisms by which neuropsychiatric syndromes are distinguished from movement disorders through differences in D1R and D2R AAb titers, signaling, and immunoreactivity.
- This study could inform new diagnostic and treatment options for GAS sequelae and related disorders.
Gabriella True
