Felger JC, Miller AH. Cytokine effects on the basal ganglia and dopamine function: the subcortical source of inflammatory malaise. Front Neuroendocrinol. 2012 Aug;33(3):315-27. doi: 10.1016/j.yfrne.2012.09.003. Epub 2012 Sep 21. PMID: 23000204; PMCID: PMC3484236.
- Cytokines released during inflammation target the basal ganglia and dopamine
- Cytokines can disrupt dopamine function by effects on synthesis, packaging, release, and reuptake
- Cytokine effects on basal ganglia dopamine may cause anhedonia, fatigue, and psychomotor slowing
- Cytokines may contribute to behavioral disorders associated with chronic inflammation