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Lyme Borreliosis and Associations With Mental Disorders and Suicidal Behavior: A Nationwide Danish Cohort Study
Fallon BA, Madsen T, Erlangsen A, Benros ME. Lyme Borreliosis and Associations With Mental Disorders and Suicidal Behavior: A Nationwide Danish Cohort Study. Am J Psychiatry. 2021 Oct 1;178(10):921-931. doi: 10.1176/appi.ajp.2021.20091347. Epub 2021 Jul 28. PMID: 34315282.
  • Results showed that individuals with Lyme borreliosis had higher rates of mental disorders, affective disorders, suicide attempts, and death by suicide compared to those without Lyme borreliosis.
  • The 6-month interval after diagnosis had the highest rate of any mental disorder, and the first 3 years after diagnosis had the highest rate of suicide.
  • Multiple episodes of Lyme borreliosis were associated with increased incidence rate ratios for mental disorders, affective disorders, and suicide attempts.
  • Clinicians should be mindful of the potential psychiatric consequences of Lyme borreliosis, despite the low absolute population risk.
COVID-19 Infection: A Neuropsychiatric Perspective

Theodora A. Manolis, M.D., Evdoxia J. Apostolopoulos, B.Sc., Antonis A. Manolis, M.S., B.Sc., Helen Melita, M.D., Antonis S. Manolis, M.D., COVID-19 Infection: A Neuropsychiatric Perspective. 19 Jul 2021. Jnl of Neuropsychiatry & Clinical Neurosciences. DOI: 10.1176/appi.neuropsych.20110277

“In addition to acute neuropsychiatric manifestations, COVID-19 may also produce late neuropsychiatric sequelae as a function of the psychoneuroimmunological cascade that it provokes. The present article presents a state-of-the-science review of these issues through an integrative review and synthesis of case series, large-cohort studies, and relevant meta-analyses. Heuristics for evaluation and further study of the neuropsychiatric manifestations of SARS-CoV-2 infection are offered.”

Allergic diseases influence symptom severity and T lymphocyte subgroups of children with tic disorders
Liu X, Wang X, Zhang X, et al. Allergic diseases influence symptom severity and T lymphocyte subgroups of children with tic disorders. Jnl Investigative Medicine. 13 July 2021. DOI: 10.1136/jim-2021-001788
  • Reviews the severity of tics and T lymphocyte subgroups in patients with tic disorders and allergic diseases
  • 85 children (ages 6-10)- Compared TD but no allergic disease with chronic allergic diseases (including allergic rhinitis, atopic dermatitis, asthma) and tic disorders (TD)
  • Children with TD plus allergic diseases have heavier motor and vocal tic symptoms
  • Children with TD plus allergic diseases had significantly lower levels of CD3, CD4, and CD4:CD8 than those with TD without allergic diseases
  • Allergic disease aggravates imbalance of T lymphocyte subsets and cellular immune

    dysfunction in children with TD
  • Allergic diseases increased illness severity and cellular immune function is increased in children with TD
  • Treat and prevent allergic diseases in children starting at diagnosis of TD
Breastfeeding in Pediatric Acute-Onset Neuropsychiatric Syndrome: An Italian Observational Study

Murciano M, Biancone DM, De Luca F, Piras MD, Guido CA, Spalice A. Breastfeeding in Pediatric Acute-Onset Neuropsychiatric Syndrome: An Italian Observational Study. Frontiers in Pediatrics. Vol 9. 2021. DOI:10.3389/fped.2021.682108

  • Looks at neurodevelopmental evolution and problems among 52 children with PANS who were Human Milk only (HMO), received formula, or had mixed feedings
  • PANS patients fed HMO reported fewer cases of growth problems, school performance problems or the need for school support, and a delay in the age of babbling/speaking compared to the other patients
  • Further studies needed to investigate the mechanisms underlying PANS role HMO may play in their short- and long-term neurodevelopment

 

DIAGNOSTICS, DIFFERENTIAL DIAGNOSTICS AND TREATMENT OF PANDAS SYNDROME: DESCRIPTION OF THE CASE

DIAGNOSTICS, DIFFERENTIAL DIAGNOSTICS AND TREATMENT OF PANDAS SYNDROME: DESCRIPTION OF THE CASE. Mukhtorjonova Khusnigul Nodirbekovna, Elmurodova Zarina Aslanovna. Matkarimova Dilnoza Doniyorovna, Tashkent Pediatric Medical Institute. ISSN: 2776-0960 Volume 2, Issue 6, June 2021

The analysis of this clinical case demonstrates the existence of a group of patients with a good therapeutic response to the administration of immunoglobulins and antibiotics. The mechanisms of development and course of this condition are not fully understood and require further research.