Prevalence of Neurological Soft Signs at Presentation in Pediatric Acute-Onset Neuropsychiatric Syndrome

Jane E. Zebrack, Jaynelle Gao, Britta Verhey, Lu Tian, Christopher Stave, Bahare Farhadian, Meiqian Ma, Melissa Silverman, Yuhuan Xie, Paula Tran, Margo Thienemann, Jenny L. Wilson, Jennifer Frankovich,  Prevalence of Neurological Soft Signs at Presentation in Pediatric Acute-Onset Neuropsychiatric Syndrome medRxiv 2024.04.26.24306193; doi: https://doi.org/10.1101/2024.04.26.24306193
  • 79.8% had at least one NSS-BG (neurological soft signs/behaviors).
  • Average of 2.1 NSS-BG per patient.
  • More NSS-BG = higher global impairment and more symptoms.
  • Regression Results:
    • NSS-BG correlated with global impairment and symptom count (p=0.045 and p=0.002, respectively).
    • No correlation with age or PANS duration at presentation.
  • Conclusions:
    • High NSS-BG prevalence in PANS.
    • NSS-BG linked to severity, not age.
    • Suggests targeted neurological exams could aid PANS diagnosis.

Gabriella True

Gabriella True

Published : April 26, 2024
Category : Blog, Research

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