Pediatric Acute-Onset Neuropsychiatric Syndrome with Capgras Syndrome

Sharawat IK, Panda PK, Gupta R. Pediatric Acute-Onset Neuropsychiatric Syndrome with Capgras Syndrome. Ann Indian Acad Neurol. 2021;24(4):600-601. doi:10.4103/aian.AIAN_959_20
This is believed to be the first reported case of Capgras syndrome in a child with PANS. A 9-year-old girl developed an acute onset of OCD behaviors, anorexia and emotional lability. Capgras syndrome is characterized by a specific monothematic delusion in which the patient believes that his/her relatives have been substituted by impostors who bear a close resemblance with the originals.
  • 3 weeks before symptoms, had acute pharyngotonsillitis, positive for strep.
  • Five days into the illness- increase in abnormal behavior and refused to recognize parents. Said they were replaced by some imposters and they are trying to hurt her.
  • Treated with Augmentin – OCD reduced in severity, appetite improved, started to acknowledge parents
Authors conclude: “Clinicians need to be aware of this rare monothematic delusion, as complete resolution can be achieved with timely treatment.”

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