Oxidative stress and gut-derived lipopolysaccharides in children affected by paediatric autoimmune neuropsychiatric disorders associated with streptococcal infections

Loffredo, L., Spalice, A., Salvatori, F., De Castro, G., Guido, C. A., Zicari, A. M., Ciacci, P., Battaglia, S., Brindisi, G., Ettorre, E., Nocella, C., Salvatori, G., Duse, M., Violi, F., & Carnevale, R. (2020). Oxidative stress and gut-derived lipopolysaccharides in children affected by paediatric autoimmune neuropsychiatric disorders associated with streptococcal infections. BMC pediatrics, 20(1), 127. https://doi.org/10.1186/s12887-020-02026-8

“This study shows that children affected by PANDAS have high circulating levels of sNOX2-dp, isoprostanes and of LPS that could be involved in the process of neuroinflammation.”

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