Xu J, Frankovich J, Liu RJ, Thienemann M, Silverman M, Farhadian B, Willet T, Manko C, Columbo L, Leibold C, Vaccarino FM, Che A, Pittenger C. Elevated antibody binding to striatal cholinergic interneurons in patients with pediatric acute-onset neuropsychiatric syndrome. Brain Behav Immun. 2024 Jul 29:S0889-1591(24)00515-4. doi: 10.1016/j.bbi.2024.07.044. Epub ahead of print. PMID: 39084540.
- Children with PANS had lower levels of IgG antibodies (a type of immune protein) in their plasma during a symptom flare compared to matched controls.
- PANS IgG drawn at flare shows elevated binding to CINs in both mouse and human brain.
- PANS IgG binding to CINs reduces their activity using p-rpS6 as a marker.
- Reduction of PANS IgG binding to CINs parallels symptom improvement during recovery.
- Elevated IgG binding to CINs is resolved in the same subject during symptom recovery.
- The study suggests that at least a subset of PANS cases have a neuroimmune pathogenesis.
Gabriella True
