Golovchenko M, Opelka J, Vancova M, Sehadova H, Kralikova V, Dobias M, Raska M, Krupka M, Sloupenska K, Rudenko N. Concurrent Infection of the Human Brain with Multiple Borrelia Species. Int J Mol Sci. 2023 Nov 29;24(23):16906. doi: 10.3390/ijms242316906. PMID: 38069228; PMCID: PMC10707132.
- Lyme disease (LD) spirochetes invade tissues, including the brain.
- Immune evasion tactics: immune suppression, tolerance, antigenic variation, intracellular hiding, biofilms, and persistent forms.
- Immune-privileged site invasion (e.g., brain) shields spirochetes from immune response and antibiotics.
- Case study: Spirochetal DNA found in multiple brain regions of a deceased LD patient.
- Co-infection detected: Borrelia burgdorferi and Borrelia garinii in distinct, non-overlapping brain areas.
- Atypical spirochete morphology observed in both human and experimentally infected mouse brain tissue.
Gabriella True
