Masterson EE, Gavin JM. Baseline characteristics of children in the International PANS Registry (IPR) Epidemiology Study. BMJ Open. 2024 Jan 24;14(1):e072743. doi: 10.1136/bmjopen-2023-072743. PMID: 38267248; PMCID: PMC10824037.
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- Participants & Household Composition: 1,781 individuals (1,179 cases, 602 siblings) from 1,010 households; 39% include a sibling, and 20% have multiple cases.
- Enrollment Age: Mean age was 11.3 years for cases and 10.1 years for siblings.
- PANS-like Features: Anxiety (94%), emotional lability (92%), and obsessions (90%) were the most common symptoms.
- Onset Patterns: 95% had a sudden or dramatic onset, either initially or following gradual progression; early signs began around age 4, with dramatic increases around age 7.
- Symptom Triggers & Treatment: Infection/illness triggered symptoms in 84% of cases; 88% were treated with antibiotics and 79% with NSAIDs.
- Immune-related Conditions: Reported in 18% of cases and 48% of nuclear, biological families, with 39% in biological mothers.
Gabriella True
