Basal ganglia inflammation in children with neuropsychiatric symptoms

Ajay Kumar, Mitchel Williams, Otto Muzik and Harry Chugani
Journal of Nuclear Medicine–2015

Our findings suggest increased activated microglial cells, suggesting underlying neuroinflammation, in bilateral caudate nuclei in children with PANDAS and TS and in bilateral lentiform nuclei in PANDAS patients only. These differences in the pattern and extent of neuroinflammation signify a possible difference in pathophysiological etiology between PANDAS and TS.

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