Blog - Aspire

Paediatric Autoimmune Neuropsychiatric Disorder Associated with Group A Beta-Haemolytic Streptococcal Infection: An Indication for Tonsillectomy? A Review of the Literature

Published: Feb 21, 2018 | Author: Aspire | Category: Blog, Research | Tags: Tonsillectomy | No Comments

Rajgor AD, Hakim NA, Ali S, Darr A. Int J Otolaryngology-2018 PDF PANDAS is a significantly debilitating condition, with detrimental effects on a child’s psychophysical development. This review provides an […]

Mannose-Binding Lectin 2 Gene Polymorphism in PANDAS Patients

Published: Jan 1, 2018 | Author: Aspire | Category: Blog, Research | No Comments

Gonca Gul Celik, Didem Arslan Tas, Aysegul Yolga Tahiroglu, Eren Erken, Gulsah Seydaoglu, Perihan Cam Ray, Ayse Avci Arch. Neuropsychiatry-2018 PDF Based on the present findings, we conclude that MBL2 […]

Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection (PANDAS): Clinical Manifestations, IVIG Treatment Outcomes, Results from a Cohort of Italian Patients

Published: Jan 1, 2018 | Author: Aspire | Category: Blog, Research | Tags: IVIG | No Comments

Piero Pavone, Raffaele Falsaperia, Francesco Nicita, Andreana Zecchini, Chiari Battaglia, Alberto Spalice, Lucia Iozzi, Enrico Parano, Giovanna Vitaliti, Alberto Verrotti, Vincenzo Belcastro, Sung Yoon Cho, Dong-Kyu Jin, Salvatore Savasta Neuropsychiatry-2018 […]

A Double-Blind Randomized Placebo-Controlled Pilot Study of Azithromycin in Youth with Acute-Onset Obsessive-Compulsive Disorder

Published: Dec 2, 2017 | Author: Aspire | Category: Blog, Research | Tags: Antibiotics | No Comments

Murphy, Brennan, Johnco, Parker-Athill, Miladinovic, Storch, Lewin J Child Adolesc Psychopharmacology-2017 This double blind pilot study suggests that azithromycin may be helpful in treating youth meeting the PANS diagnosis, especially […]

Treatment of Pediatric Acute-Onset Neuropsychiatric Disorder in a Large Survey Population

Published: Sep 1, 2017 | Author: Aspire | Category: Blog, Research | No Comments

Denise Calaprice, Janice Tona, and Tanya K. Murphy Journal of Child and Adolescent Psychopharmacology-2017 Among the PANS patients represented in this study, relatively aggressive treatment courses targeted at eradicating infection […]

Inflammation in the Neurocircuitry of Obsessive-Compulsive Disorder

Published: Aug 1, 2017 | Author: Aspire | Category: Blog, Research | Tags: Adult | No Comments

Sophia Attwells, HBS; Elaine Setiawan, PhD; Alan A. Wilson, PhD, Pablo M. Rusjan, PhD; Romina Mizrahi, MD, PhD, FRCP(C); Laura Miler, HBS; Cynthia Xu, MD; Margaret Anne Richter, MD, FRCP(C); […]

Streptococcal infection-related autoimmunity and autism: crosstalk in protein functional networks

Published: Jul 21, 2017 | Author: Aspire | Category: Blog, Research | Tags: autism | No Comments

Megan Huxley, Joshua Stead, Olga Vasieva Journal of Systems and Integrative Neuroscience-2017 From published and our study it is clear that there is overlap within the IS and NS functions […]

Association of Streptococcal Throat Infection With Mental Disorders Testing Key Aspects of the PANDAS Hypothesis in a Nationwide Study

Published: Jul 1, 2017 | Author: Aspire | Category: Blog, Research | No Comments

Sonja Orlovska, Claus Høstrup Vestergaard, Bodil Hammer Bech, PhD JAMA Psychiatry-2017 This large-scale study investigating key aspects of the PANDAS hypothesis found that individuals with a streptococcal throat infection had […]

Effect of Early and Prophylactic Nonsteroidal Anti-Inflammatory Drugs on Flare Duration in Pediatric Acute-Onset Neuropsychiatric Syndrome: An Observational Study of Patients Followed by an Academic Community-Based Pediatric Acute-Onset Neuropsychiatric Syndrome Clinic

Published: Jul 1, 2017 | Author: Aspire | Category: Blog, Research | Tags: advisory board, Anti-Inflammatory, NSAIDs | No Comments

Brown Kayla D., Farmer Cristan, Freeman G. Mark Jr., Spartz Ellen J., Farhadian Bahare, Thienemann Margo, and Frankovich Jennifer JCAP-July 2017 NSAIDs given prophylactically or within 30 days of flare […]

Course of Neuropsychiatric Symptoms After Introduction and Removal of Nonsteroidal Anti-Inflammatory Drugs: A Pediatric Observational Study

Published: Jul 1, 2017 | Author: Aspire | Category: Blog, Research | Tags: advisory board, Anti-Inflammatory, NSAIDs | No Comments

Spartz Ellen J., Freeman G. Mark Jr., Brown Kayla, Farhadian Bahare, Thienemann Margo,Frankovich, Jennifer JCAP-July 2017 Improvement in neuropsychiatric symptoms was evident in roughly one-third of NSAID treatment trials. A […]

Pediatric Acute-Onset Neuropsychiatric Syndrome Response to Oral Corticosteroid Bursts: An Observational Study of Patients in an Academic Community-Based PANS Clinic

Published: Jul 1, 2017 | Author: Aspire | Category: Blog, Research | Tags: advisory board, Anti-Inflammatory, Steroids | No Comments

Brown Kayla, Farmer Cristan, Farhadian Bahare, Hernandez Joseph, Thienemann Margo, and Frankovich Jennifer JCAP-2017 Corticosteroids may be a helpful treatment intervention in patients with new-onset and relapsing/remitting PANS and PANDAS, […]

Clinical Management of PANS: Part III—Treatment and Prevention of Infections

Published: Jul 1, 2017 | Author: Aspire | Category: Blog, Research | Tags: advisory board, JCAP 2017, Treatment Guidelines | No Comments

Cooperstock Michael S., Swedo Susan E., Pasternack Mark S., Murphy Tanya K., and for the PANS PANDAS Consortium Journal of Child and Adolescent Psychopharmacology-2017 PDF A working guideline for the […]

ASPIRE Blog

Paediatric Autoimmune Neuropsychiatric Disorder Associated with Group A Beta-Haemolytic Streptococcal Infection: An Indication for Tonsillectomy? A Review of the Literature

Mannose-Binding Lectin 2 Gene Polymorphism in PANDAS Patients

Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection (PANDAS): Clinical Manifestations, IVIG Treatment Outcomes, Results from a Cohort of Italian Patients

A Double-Blind Randomized Placebo-Controlled Pilot Study of Azithromycin in Youth with Acute-Onset Obsessive-Compulsive Disorder

Treatment of Pediatric Acute-Onset Neuropsychiatric Disorder in a Large Survey Population

Inflammation in the Neurocircuitry of Obsessive-Compulsive Disorder

Streptococcal infection-related autoimmunity and autism: crosstalk in protein functional networks

Association of Streptococcal Throat Infection With Mental Disorders Testing Key Aspects of the PANDAS Hypothesis in a Nationwide Study

Effect of Early and Prophylactic Nonsteroidal Anti-Inflammatory Drugs on Flare Duration in Pediatric Acute-Onset Neuropsychiatric Syndrome: An Observational Study of Patients Followed by an Academic Community-Based Pediatric Acute-Onset Neuropsychiatric Syndrome Clinic

Course of Neuropsychiatric Symptoms After Introduction and Removal of Nonsteroidal Anti-Inflammatory Drugs: A Pediatric Observational Study

Pediatric Acute-Onset Neuropsychiatric Syndrome Response to Oral Corticosteroid Bursts: An Observational Study of Patients in an Academic Community-Based PANS Clinic

Clinical Management of PANS: Part III—Treatment and Prevention of Infections

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