The Comprehensive Physicians’ Guide to the Management of PANS and PANDAS: An Evidence-Based Approach to Diagnosis, Testing, and Effective Treatment

The Comprehensive Physicians’ Guide to the Management of PANS and PANDAS: An Evidence-Based Approach to Diagnosis, Testing, and Effective Treatment Hardcover – January 30, 2024

By Dr. Scott Antoine

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An evidence-based guide for doctors diagnosing, testing, and treating children with PANDAS (Pediatric Autoimmune Neuropsychiatric Disorder Associated with Strep infections).

In the early 1990s, a group of researchers at the National Institute of Mental Health began collecting data on children who had developed neuropsychiatric disorders (OCD and tics) following infections. They found evidence that antineuronal antibodies had developed in some of these children which attacked the basal ganglia region of the brain. MRI and PET scans in these children demonstrated inflammatory changes in the basal ganglia as well. In 1997, the researchers published the first article to describe this syndrome that they named PANDAS (Pediatric Autoimmune Neuropsychiatric Disorder Associated with Strep infections).