Please note. This is not meant to be a comprehensive list. These are studies we have found helpful in referencing.
Histamine + OCD / compulsive behavior (mechanistic + animal + translational)
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7749329/
(Histamine H3 receptor modulation alters repetitive/compulsive behaviors) - https://pmc.ncbi.nlm.nih.gov/articles/PMC8317266/
(Histamine, neuroinflammation, and neurodevelopment; links to OCD/Tourette pathways) - https://www.sciencedirect.com/science/article/abs/pii/S0028390818302661
(Enhanced histaminergic transmission attenuates compulsive-like behavior) - https://www.pnas.org/doi/10.1073/pnas.0809479105
(Brain mast cells influence behavior via histamine signaling) - https://www.preprints.org/manuscript/202602.0271/v1
(Histamine regulation of cortico-striatal circuits relevant to OCD)
MCAS / mast cells + neuropsychiatric symptoms (includes OCD-relevant pathways)
- https://www.sciencedirect.com/science/article/pii/S2666354625001061
(Mast Cell Activation Syndrome associated with increased neuropsychiatric disorders; improvement with treatment noted) - https://pmc.ncbi.nlm.nih.gov/articles/PMC10672129/
(Neuropsychiatric manifestations of mast cell activation) - https://www.frontiersin.org/articles/10.3389/fnins.2021.680214/full
(Mast cells, histamine, and neuroinflammation in the brain)
Histamine / immune / gut links to compulsive behavior
- https://www.sciencedirect.com/science/article/abs/pii/S0306987722000391
(Gut barrier dysfunction, histamine, dopamine, and compulsive behavior)
Allergy / immune activation influencing OCD symptoms
- https://pmc.ncbi.nlm.nih.gov/articles/PMC4673718/
(Allergic disease associated with increased OCD/anxiety symptoms)
Gabriella True
