PANDAS Physicians Network An Overview for Diagnosing and Treating PANS/PANDAS Susan E. Swedo, MD – Scientist Emeritus at the National Institute of Health Complete CME Webinar: Online PANS...
Mona Gerentes, Antoine Pelissolo, Krishnamoorthy Rajagopal, Ryad Tamouza, Nora Hamdani,
Anxiety Disorders-August 2019
This review highlights that OCD is associated with low-grade inflammation, neural antibodies, and neuro-inflammatory and auto-immune disorders. In some subset of OCD patients, autoimmunity is likely triggered by specific bacterial, viral, or parasitic agents with overlapping surface epitopes in CNS. Hence, subset-profiling in OCD is warranted to benefit from distinct immune-targeted treatment modalities.
One might think, because PANDAS/PANS strikes children, passing the bill would be a slam dunk, but Uttam said it’s failed twice in Massachusetts already. It has, however, passed in five other...
B. Joubert, J.Dalmau
International meeting of the French society of neurology & SPILF 2019
Abstract: Autoimmune encephalitides are autoimmune neurological disorders characterized by rapidly progressive central nervous system symptoms associated with specific auto-antibodies targeting neuronal cell-surface proteins. The clinical features of encephalitis are frequently preceded by symptoms suggesting an infectious process, and specific pathogens have been detected at the early phase of the disease in some patients, suggesting that it can be triggered by infections. Moreover, recent data have shown an association with specific HLA haplotypes, suggesting a genetic susceptibility to develop at least some subtypes of autoimmune encephalitis. Nonetheless, the immunological mechanisms leading from an adequate response to infection to autoimmunity against neuronal self-antigens remain highly hypothetical. Molecular mimicry, inborn errors of the host immune system, as well as epitope spreading and chronic activation of innate immunity actors, may be involved. Importantly, the frequency of prodromal infectious symptoms and association with HLA haplotypes differ among autoimmune encephalitides, suggesting that depending on the subtype distinct immunopathogenic mechanisms are involved. A direct link between infection and autoimmune encephalitis was recently provided by the demonstration that most of the so-called relapsing neurological symptoms post-herpes simplex virus encephalitis corresponded to viral-induced autoimmune encephalitis with antibodies against NMDA receptors or other, yet unknown, neuronal surface antigens. Although this association has also been demonstrated experimentally in mice, the underlying immunological mechanisms remain unknown. Overall, a body of clinical, epidemiological and experimental data suggests infections are involved in the pathogenesis of autoimmune encephalitides. Further studies, focusing on the interplays between pathogens, genetic determinants of the host immune response, and brain inflammation, are needed to clarify the immunological mechanisms that lead to autoimmune encephalitis after infection.
Avis Chan and Jennifer Frankovich
Journal of Child and Adolescent Psychopharmacology-2019
I’ve been talking a lot recently about my experience of having Paediatric Acute-Onset Neuropsychiatric Syndrome (an illness which, despite its name, affects adults too), and how I was undiagnosed...
S. Cocuzza, S. Marino, A. Gulino, E. Pustorino, P. Murabito, A. Maniaci, L. Sabino, R. Taibi, M. Di Luca, R. Falsaperla, G. Campione, M. Vecchio, P. Pavone
Eur Rev Med Pharmacol Sci-2019
Findings from our study show that respiratory diseases, characterizing a group of patients with pandas, are the direct consequences of the malformed or hypertrophic condition and suggesting in these conditions surgical therapy as an approaching tool.
OCONOMOWOC — Eliza Ellis should be taking her first steps into adulthood. Instead, the 19-year-old requires around-the-clock care in her Oconomowoc home. "Always thought that right after high...
Nursing considerations Nurses must educate patients and parents to monitor for any signs and symptoms of recurring infection, specifically GAS infection, in the patient or in any of the patient's...
What will follow will be a combination of my thoughts on the situation up-to-date; answers to many of the questions I have received over the years and some suggestions for future work. To foreshadow...
Stanford University School of Medicine Presented by the Departments of Pediatrics and Psychiatry and Behavioral Health at the Stanford University School of Medicine Margo Thienemann, MD –...
Lisa Rinna is opening up about her daughter’s struggles with mental health. On Monday, just three days after Delilah Belle Hamlin revealed she had been to rehab two times last year, Rinna shared...