Santoro JD, Frankovich J, Bhargava S. Continued Presence of Period Limb Movements During REM Sleep in Patients With Chronic Static Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS). J Clin Sleep Med. 2018 Jul 15;14(7):1187-1192. doi: 10.5664/jcsm.7222. PMID: 29991427; PMCID: PMC6040797.
- Small retrospective PSG study of 9 pediatric PANS patients with chronic, treatment-refractory symptoms (median 4 years after onset).
- 7 of 9 showed elevated periodic limb movements during REM sleep.
- 2 also had REM sleep without atonia, though not full REM sleep behavior disorder.
- Delayed REM onset, reduced total sleep time, and decreased sleep efficiency were common
- Takeaway: Sleep disruption can persist years into chronic PANS and may contribute to ongoing symptom burden.
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