Microglial Dysregulation in OCD, Tourette Syndrome, and PANDAS

Luciana Frick, Christopher Pittenger, “Microglial Dysregulation in OCD, Tourette Syndrome, and PANDAS”, Journal of Immunology Research, vol. 2016, Article ID 8606057, 8 pages, 2016. https://doi.org/10.1155/2016/8606057

Mechanisms by which microglial abnormalities contribute to disease are likely to be shared across distinct etiologies and traditional diagnoses. For instance, abnormal synaptic pruning was observed both in animals inoculated with GAS (which may capture key elements of the pathophysiology of PANDAS) and in mice that develop excessive grooming after inactivation of the progranulin gene. In both cases, increased synaptic pruning cooccurs with microglia activation.

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