Melamed, Isaac, et al.“IVIG Response in Pediatric Acute-onset Neuropsychiatric Syndrome Correlates with Reduction in Pro-inflammatory Monocytes and Neuropsychiatric Measures.”Frontiers in Immunology, vol. 15, 2024, p. 1383973, https://doi.org/10.3389/fimmu.2024.1383973. Accessed 3 Oct. 2024.
- Study aimed to investigate the pro-inflammatory state in PANS patients before and after IVIG treatment.
- Ten male PANS patients (ages 6–16) received six IVIG infusions over 3 weeks.
- Blood samples and psychiatric assessments were taken before treatment and at follow-up points (4 and 11 weeks post-treatment).
- Myeloid cell activation was analyzed using flow cytometry.* Significant improvement in all psychiatric assessments and parent-reported outcomes (CY-BOCS, YGTSS, and PANS rating scales; all p<0.001).
- Pro-inflammatory monocytes and dendritic cells significantly decreased after IVIG.
- Reduction in pro-inflammatory monocytes was observed both proportionally and in absolute numbers.
Gabriella True
