Tang AW, Swedo SE, Pasternack M, Murphy T, et al. Eight cases of pediatric acute-onset neuropsychiatric syndrome: clinical characteristics. Developmental Neuroscience. 2025;47(4):287–302. doi:10.1159/000543969
Please read more in depth blog – When PANS and IBD Co-Occur: What This Case Series Suggests
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Identifies a subgroup of children with PANS characterized by the triad of PANS symptoms, joint complaints, and family history of autoimmunity (including psoriasis).
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Suggests this subgroup may be at increased risk for inflammatory bowel disease and other immune-mediated disorders.
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Recommends a low threshold for evaluation of gastrointestinal inflammation using biomarkers such as hemoglobin, CRP, fecal calprotectin, and endoscopy when indicated.
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Reports that PANS symptoms may improve with effective treatment of inflammatory bowel disease.
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Notes high prevalence of joint complaints and autoimmune family history, suggesting shared immune mechanisms with psoriasis and arthritis.
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Proposes that treatments used in inflammatory bowel disease and arthritis warrant study for potential application in PANS.
Gabriella True
