
Oregon PANS PANDAS Updates
Please support NWPPN’s lead to mandate insurance coverage for PANS...
Please support NWPPN’s lead to mandate insurance coverage for PANS...
Speaker: Marla W. Deibler, PsyD, ABPP Webinar: Maximizing Family Support in PANS / PANDAS Date/Time: Thursday, May 18th, at 12:00pm EST Register for this webinar: Via Zoom About this Webinar...
Missouri PANS PANDAS Updates Currently, there is a proposed PANS PANDAS bill in the House – Proposed HB 1365 Requires health insurance coverage of certain pediatric disorders that would...
Thank you to everyone who took a moment to celebrate the successes of the past year so our community can carry hope into 2023! ...
Felger JC, Miller AH. Cytokine effects on the basal ganglia and dopamine function: the subcortical source of inflammatory malaise. Front Neuroendocrinol. 2012 Aug;33(3):315-27. doi: 10.1016/j.yfrne.2012.09.003. Epub 2012 Sep 21. PMID: 23000204; PMCID: PMC3484236.
Dedication to PANS/PANDAS Awareness and Advocacy with Advocate Gabriella True “It’s not always about overcoming, it’s about living.” Gabriella True Link to Podcast Episode on...
TACA’s Take Action Conference Series is an entirely new offering for TACA families. This virtual month-long opportunity will include live lectures from experts, take-action workshops,...
CDC’s Autism Numbers – 1 in 36 The newly published estimated Autism Prevalence rates by the Center for Disease Control and Prevention (CDC) report that 1 in 36 children...
Runge, K., Reisert, M., Feige, B. et al. Deep clinical phenotyping of patients with obsessive-compulsive disorder: an approach towards detection of organic causes and first results. Transl Psychiatry 13, 83 (2023). https://doi.org/10.1038/s41398-023-02368-8
A relevant number of organic OCD forms (in 16%) were identified, which in 5% of all patients lead to successful treatment with immunotherapies. The frequent presence of autoantibodies such as anti-TPO or ANA further support the possible influences of autoimmune processes in OCD [16]. Further findings may well have modulatory effects on the course of the disease (e.g., substitution of folic acid deficiency). In addition, these findings might have a positive influence on the disease concept and self-image of affected patients and their relatives. The establishment of diagnostic regimens such as FDP-OCD should be evaluated in larger prospective and controlled studies. This could allow for a specific treatment of a small subgroup of patients with identified organic OCD reducing treatment resistance.
Dr. Daines and the team at the CPAE Center of Excellence (University of Arizona) recently conducted a poster presentation at the AAAAI. The study demonstrates the beneficial effects of IVIG treatments for PANS patients. 11 out of 12 PANS patients showed “significant” improvement following IVIG treatment.
The significant presence of baseline hypogammaglobulinemia in children with PANS emphasizes the presumed role of immune dysfunction in disease pathogenesis, especially given the known connection between immunodeficiency and autoimmunity (8,9). Thus, immunomodulatory interventions are presumed to have a crucial therapeutic role.
It did not assess the benefit of IVIG for OCD or Restricted Eating as the other psychiatric, and neuropsychological manifestations can sometimes overshadow OCD (1-3). Since objective post-treatment evaluations are scarce and challenging given disease complexity (5-7), the study used standardized neuropsychiatric testing to assess how (IVIG) treatment impacts cognitive function in children with PANS.
The research, as presented in the poster session, will be submitted as a journal article.