PANDAS and PANS: Pathophysiology, Diagnostics and Therapeutic Approaches in Pediatric Autoimmune Neuropsychiatric Disorders – a literature review. March 2025. Journal of Education Health and Sport 79:57830. DOI:10.12775/JEHS.2025.79.57830
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Identifies a subgroup of children with PANS characterized by the triad of PANS symptoms, joint complaints, and family history of autoimmunity (including psoriasis).
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Suggests this subgroup may be at increased risk for inflammatory bowel disease and other immune-mediated disorders. Recommends a low threshold for evaluation of gastrointestinal inflammation using biomarkers such as hemoglobin, CRP, fecal calprotectin, and endoscopy when indicated.
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Reports that PANS symptoms may improve with effective treatment of inflammatory bowel disease.
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Notes high prevalence of joint complaints and autoimmune family history, suggesting shared immune mechanisms with psoriasis and arthritis.
Gabriella True
