February 27, 2025
Iowa PANS PANDAS Updates
The deadline to make the first funnel is March 4th. Calls/emails really need to be made by Monday, March 1st as this committee generally only meets on...
February 25, 2025
Restricted Eating & PANS Zoom ChitChat
Zoom - Restricted Eating ChitChat - Tuesday, April 1 - 6:30 PM CT...
February 19, 2025
Virginia PANS PANDAS Updates
Virginia PANS PANDAS Updates Virginia Alliance for PANS/PANDAS Action (VA4PA) is leading legislative efforts. Please contact them directly for more information. Their website is VA4PA and...
February 18, 2025
Homeschooling and PANS/PANDAS: Resources for Families
Homeschooling and PANS/PANDAS: Resources for Families Traditional school environments can be challenging for many families navigating PANS/PANDAS. Symptoms such as anxiety, OCD, cognitive...
Fluoxetine promotes IL-10-dependent metabolic defenses to protect from sepsis-induced lethality
Gallant RM, Sanchez KK, Joulia E, Snyder JM, Metallo CM, Ayres JS. Fluoxetine promotes IL-10-dependent metabolic defenses to protect from sepsis-induced lethality. Sci Adv. 2025 Feb 14;11(7):eadu4034. doi: 10.1126/sciadv.adu4034. Epub 2025 Feb 14. PMID: 39951524; PMCID: PMC11827869.
- SSRIs Overview: Among the most prescribed drugs globally, primarily used to enhance serotonergic signaling in the brain.
- Beyond the Brain: SSRIs also impact immune and metabolic functions.
- Infection Protection: Studies show SSRIs, including fluoxetine, protect against infections like sepsis and COVID-19, though mechanisms remain unclear.
- Key Findings on Fluoxetine:Protection is independent of peripheral serotonin.
- Increases circulating interleukin-10 (IL-10) levels.
- IL-10 prevents sepsis-induced hypertriglyceridemia and associated cardiac issues (glucose oxidation impairment, lipid accumulation, ventricular stretch, potential cardiac failure).
- Therapeutic Potential: Fluoxetine’s “off-target” effects offer a protective immunometabolic mechanism with possible clinical applications.
February 14, 2025
Washington State PANS PANDAS Updates
For up-to-date information on Oregon’s legislative action: Make sure to follow NWPPN’s Facebook page for updates and questions. To contact NWWP directly, please email them – NWPPN’s...
February 14, 2025
Resources for Eating Restrictions in PANS/PANDAS
Restricted eating, including Avoidant/Restrictive Food Intake Disorder (ARFID), is a common yet complex challenge for individuals with PANS/PANDAS. Families and patients often struggle to find...
February 12, 2025
Health Insurers Deny 850 Million Claims a Year
The Becks paid $20,000 out-of-pocket in 2023 for Emily’s medical care, including occupational therapy, psychiatric appointments, tests, supplements and medications that insurance wouldn’t pay for...
February 1, 2025
Louisiana Zoom ChitChat
Zoom - Louisiana ChitChat - Thursday, February 27 - 3:00 PM CT...
January 17, 2025
NJSSNA Spring 2025 Conference Pearls of Wisdom for School Nurses
ASPIRE to Speak at NJSSNA Spring 2025 Conference – Pearls of Wisdom for School Nurses Conference Details Friday, March 28, 2025 at 6:00pm ET – Saturday, March 29,...
January 17, 2025
IgNS Virtual Conference Exhibitors
We’re Exhibiting at the Patient 360 Virtual Conference! ASPIRE is excited to join the IgNS Patient 360 Virtual Conference on March 8–9, 2025! This FREE, two-day event connects patients,...