Prevalence and treatment response of neuropsychiatric disorders in mast cell activation syndrome

Weinstock LB, Afrin LB, Reiersen AM, Brook J, Blitshteyn S, Ehrlich G, Schofield JR, Kinsella L, Kaufman D, Dempsey T, Molderings GJ. Prevalence and treatment response of neuropsychiatric disorders in mast cell activation syndrome. Brain, Behavior, & Immunity – Health. 2025;48:101048.doi:10.1016/j.bbih.2025.101048

  • MCAS is a common inflammatory disease characterized by mast cell dysregulation.
  • 19 neurologic and 14 psychologic disorders were significantly increased in MCAS subjects.
  • Chemical mediators, genetic predisposition, and life experiences could determine which disorders occur or worsen.