IVIG response in pediatric acute-onset neuropsychiatric syndrome correlates with reduction in pro-inflammatory monocytes and neuropsychiatric measures
Melamed, Isaac, et al.IVIG Response in Pediatric Acute-onset Neuropsychiatric Syndrome Correlates with Reduction in Pro-inflammatory Monocytes and Neuropsychiatric Measures.”Frontiers in Immunology, vol. 15, 2024, p. 1383973, https://doi.org/10.3389/fimmu.2024.1383973. Accessed 3 Oct. 2024.
  • Study aimed to investigate the pro-inflammatory state in PANS patients before and after IVIG treatment.
  • Ten male PANS patients (ages 6–16) received six IVIG infusions over 3 weeks.
  • Blood samples and psychiatric assessments were taken before treatment and at follow-up points (4 and 11 weeks post-treatment).
  • Myeloid cell activation was analyzed using flow cytometry.* Significant improvement in all psychiatric assessments and parent-reported outcomes (CY-BOCS, YGTSS, and PANS rating scales; all p<0.001).
  • Pro-inflammatory monocytes and dendritic cells significantly decreased after IVIG.
  • Reduction in pro-inflammatory monocytes was observed both proportionally and in absolute numbers.
Bennett’s PANS PANDAS Story
Bennett’s PANS PANDAS Story

  Bennett was a typically developing 7-year-old boy when he started second grade, the first year back to school full time after COVID-19, without masks. That December, he came down...

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The Story of Emily The Great
The Story of Emily The Great

This is the journey of Emily, who is now 16. She began experiencing PANS symptoms in 2020 during the height of COVID-19; before that, Emily was a typical kid and did all the things that girls her age...

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Obsessive Compulsive Disorder and Other Specified Anxiety Disorder in an 8-Year-Old Post-respiratory Infection: A Case Report

Tran, Michael; Amador, Alcides; and Camacho Bermudez, Sofia, “Obsessive Compulsive Disorder and Other Specified Anxiety Disorder in an 8-Year-Old Post-respiratory Infection: A Case Report” (2024). Research Colloquium. 91.https://scholarworks.utrgv.edu/colloquium/2024/posters/91

Conclusions: This case underscores the importance of considering infectious etiologies in the differential diagnosis of sudden-onset psychiatric symptoms in pediatric patients. The positive response to Sertraline and the proposed CBT highlights the potential benefits of a combined pharmacological and therapeutic approach in managing OCD and anxiety disorders. Continued follow-up and treatment adaptation is essential to ensure sustained improvement and quality of life for pediatric patients with similar presentations.