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Our Rainbow in this Storm
Our Rainbow in this Storm

My message to parents is to listen to your child and trust yourself. We all have strong parental instincts for a reason. I know there will be days when all you want to do is hide under the covers and...

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Association of Pediatric Acute-Onset Neuropsychiatric Syndrome With Microstructural Differences in Brain Regions Detected via Diffusion-Weighted Magnetic Resonance Imaging

Zheng J, Frankovich J, McKenna ES, et al. Association of Pediatric Acute-Onset Neuropsychiatric Syndrome With Microstructural Differences in Brain Regions Detected via Diffusion-Weighted Magnetic Resonance Imaging. JAMA Netw Open. 2020;3(5):e204063. doi:10.1001/jamanetworkopen.2020.4063

In this case-control study of 34 consecutive patients with pediatric acute-onset neuropsychiatric syndrome who had 3 Tesla magnetic resonance imaging, all assessed brain regions, particularly the deep gray matter (eg, the thalamus, basal ganglia, and amygdala), had statistically significantly increased mean diffusivity compared with 64 control participants. These diffusion abnormalities are consistent with the cardinal clinical symptoms of these patients, including obsessions, compulsions, emotional dysregulation, and sleep disturbances.

Meaning  Diffusion-weighted magnetic resonance imaging may offer valuable quantitative information to assist with the diagnostic workup of pediatric acute-onset neuropsychiatric syndrome.

Nurses & PANS PANDAS
May 4, 2020
Nurses & PANS PANDAS

Nurses’ Role in PANS/PANDAS What role do nurses play in helping families with PANS/PANDAS? Nurses are an integral part of the team. Nurses are often the first point of contact...

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Chasing Ghosts
Chasing Ghosts

For my son, symptom onset was not overnight. He had so many health issues starting the first few weeks of life, which continued throughout his early childhood. His body was in a near-constant state...

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Family Story – It Was Not Autism
Family Story – It Was Not Autism

April 12th, 2019, is a day I will never forget. It was exactly one week after my daughter's 4th birthday, a Friday. Springtime, my favorite time of the year, the buds of my favorite wisteria, were...

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