Imagine a child suffering from seizures, only to discover years later that the cause might be tied to a cat scratch and an insect bite. A groundbreaking case study from North Carolina State...
Students with PANS/PANDAS have complex cognitive, behavioral, physical & neurological symptoms that affect their school performance. The school's multidisciplinary team benefits from an awareness of...
Living with a sibling affected by PANS profoundly impacts well-being—fear of outbursts, limited social opportunities, and the isolation of not having the words or knowledge to explain the...
Supporting Students with PANS, PANDAS, and Basal Ganglia Encephalitis: Children with PANS, PANDAS, and basal ganglia encephalitis often require specific school accommodations to support their...
Needle fear is real, and you’re not alone. Whether it’s a quick blood draw or a longer infusion, anxiety can make the experience stressful. For those with PANS/PANDAS, it may...
The bill is going to be a huge step forward, but Emily‘s mom April says it’s not a cure the bill does not mandate insurance coverage for the most common and effective...
Fekete, R., Simats, A., Bíró, E., Pósfai, B., Cserép, C., Schwarcz, A., Szabadits, E., Környei, Z., Tóth, K., Fichó, E., Szalma, J., Vida, S., Kellermayer, A., Dávid, C., Acsády, L., Kontra, L., Silvestre-Roig, C., Moldvay, J., … Dénes, Á. (2025). Microglia dysfunction, neurovascular inflammation and focal neuropathologies are linked to IL-1- and IL-6-related systemic inflammation in COVID-19. Nature Neuroscience, 28(3), 558–576. DOI: 10.1038/s41593-025-01871-z
Neuropathological study examining brains of individuals with COVID-19.
Identifies microglial dysfunction, astrocyte involvement, and neurovascular inflammation linked to systemic IL-1 and IL-6 signaling.
Demonstrates blood–brain barrier disruption and gliovascular pathology even in the absence of direct viral invasion of brain tissue.
Provides strong evidence for self-sustaining inflammatory loops between peripheral immune signals and CNS cells.
Fekete R, Simats A, Bíró E, et al. Microglia dysfunction, neurovascular inflammation and focal neuropathologies are linked to IL-1- and IL-6-related systemic inflammation in COVID-19. Nat Neurosci. 2025;28(3):558-576. doi:10.1038/s41593-025-01871-z.
Impaired microglia function and vascular inflammation in COVID
Observational study evaluating Long COVID patients treated with H1/H2 antihistamines.
Reports improvement in fatigue, cognitive symptoms, tachycardia, and other systemic complaints.
Supports the hypothesis that mast cell activation contributes to Long COVID symptom persistence.
Suggests immune dysregulation—rather than viral persistence—may drive ongoing symptoms in a subset of patients.
WV needs your help asking legislators to support HB 2252: Requiring insurance coverage for treatment of pediatric autoimmune neuropsychiatric...
Trigger Warning: Self-Harm & Suicide The following story discusses experiences with self-harm, suicidal thoughts, and psychiatric hospitalization. If you are sensitive to these topics, please...