Structural and functional features of central nervous system lymphatic vessels

Antoine Louveau, Igor Smirnov, Timothy J. Keyes, Jacob D. Eccles, Sherin J. Rouhani, J. David Peske, Noel C. Derecki, David Castle, James W. Mandell, Kevin S. Lee, Tajie H. Harris & Jonathan Kipnis
Nature-2015

The research findings reported in this study challenge the dogmas regarding the immune privilege status of the central nervous system (CNS) and its isolation from the immune system by the blood-brain barrier. Functional meningeal lymphatic vessels capable of carrying immune cells and interstitial fluids from the CNS are identified and characterized. Findings provide novel understanding on how autoimmune encephalopathies, like PANS/ PANDAS, can develop when these unique lymphatic vessels malfunction. Structural and functional features of central nervous system lymphatic vessels.

Can an Infection Trigger OCD?
July 12, 2015
Can an Infection Trigger OCD?

Proposed link between infections and psychiatric disorders is still under review but gaining more recognition, resources among scientists MENLO PARK, Calif.—At the age of 7, Garrett Pohlman came...

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Clinical Evaluation of Youth with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS): Recommendations from the 2013 PANS Consensus Conference

Kiki Chang, Jennifer Frankovich, Michael Cooperstock, Madeleine W. Cunningham, M. Elizabeth Latimer, Tanya K. Murphy, Mark Pasternack, Margo Thienemann, Kyle Williams, Jolan Walter, and Susan E. Swedo, From the PANS Collaborative Consortium
Journal of Child and Adolescent Psychopharmacology-2015
PDF

On May 23 and 24, 2013, the First PANS Consensus Conference was convened at Stanford University, calling together a geographically diverse group of clinicians and researchers from complementary fields of pediatrics: General and developmental pediatrics, infectious diseases, immunology, rheumatology, neurology, and child psychiatry. Participants were academicians with clinical and research interests in pediatric autoimmune neuropsychiatric disorder associated with streptococcus (PANDAS) in youth, and the larger category of pediatric acute-onset neuropsychiatric syndrome (PANS). The goals were to clarify the diagnostic boundaries of PANS, to develop systematic strategies for evaluation of suspected PANS cases, and to set forth the most urgently needed studies in this field. Presented here is a consensus statement proposing recommendations for the diagnostic evaluation of youth presenting with PANS.