Maia A., Barahona-Corrêa B., Oliveira-Maia A.J., Oliveira J. (2021) Immune Dysfunction in Obsessive-Compulsive Disorder: From Risk Factors to Multisystem Involvement. In: Berk M., Leboyer M., Sommer I.E. (eds) Immuno-Psychiatry. Springer, Cham. DOI: 10.1007/978-3-030-71229-7_17
“Immune dysfunction has been proposed as an important component of the pathophysiology of obsessive-compulsive disorder (OCD), motivating innovative research hypotheses with potential clinical interest. In this chapter, we will review published evidence supporting a model for immune dysfunction in OCD as multifactorial, constitutive, and environmental, contributing to illness development, clinical presentation, and multisystem impact. The fact that OCD patients present comorbidity with several systemic illnesses, including auto-immune disorders, and that the majority of recognized risk factors, such as perinatal complications, traumatic life events or childhood infections, induce inflammation, motivated the development of studies trying to achieve a deeper comprehension regarding the association between inflammation and OCD.”
Artificial Neural Networks Analysis of polysomnographic and clinical features in Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS): from sleep alteration to “Brain Fog”
Gagliano A, Puligheddu M, Ronzano N, Congiu P, Tanca MG, Cursio I, Carucci S, Sotgiu S, Grossi E, Zuddas A. Artificial Neural Networks Analysis of polysomnographic and clinical features in Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS): from sleep alteration to “Brain Fog”. Nat Sci Sleep. 2021;13:1209-1224. DOI: 10.2147/NSS.S300818
- Disordered sleep represents is a cardinal symptom in patients with PANS
- Polysomnography showed abnormality in 17 out of 23 recruited subjects (73.9%).
- 8/17 children (47%) had ineffective sleep
- 10/17 (58.8%) fragmented sleep
- 8/17 (47.1%) periodic limb movement disorder (PLMD)
- 11/17 (64.7%) REM-sleep without atonia (RSWA).
- Most subjects presented more than one sleep disturbance
- Among the 19/23 patients diagnosed with Tic/Tourette disorder, 8/19 (42.1%) show PLMD and 10/19 (52.6%) RSWA
Lyme Borreliosis and Associations With Mental Disorders and Suicidal Behavior: A Nationwide Danish Cohort Study
Lyme Borreliosis and Associations With Mental Disorders and Suicidal Behavior: A Nationwide Danish Cohort Study. Brian A. Fallon, M.D., M.P.H., Trine Madsen, Ph.D., Annette Erlangsen, Ph.D., Michael E. Benros, M.D., Ph.D. Published Online:28 Jul 2021 https://doi.org/10.1176/ap
“Having more than one episode of Lyme borreliosis was associated with increased incidence rate ratios for mental disorders, affective disorders, and suicide attempts, but not for death by suicide. Individuals diagnosed with Lyme borreliosis in the hospital setting had an increased risk of mental disorders, affective disorders, suicide attempts, and suicide. Although the absolute population risk is low, clinicians should be aware of potential psychiatric sequelae of this global disease.”
Following COVID-19, a 9-year-old girl developed neuropsychiatric symptoms, including OCD-like behaviors. Her mother reports other symptoms included: "Extreme anxiety, resulting in frequent panic...