Monthly Archives:
February 2021

PANS Australia Conference
February 23, 2021
PANS Australia Conference

The conference is for parents and professionals and is completely online so available world-wide.  It will be recorded and available for viewing for ticket holders for a period of time after the...

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Perfectionism and Difficulty Controlling Thoughts Bridge Eating Disorder and Obsessive-Compulsive Disorder Symptoms: A Network Analysis

Irina A. Vanzhula, Shruti S. Kinkel-Ram, Cheri A. Levinson. Perfectionism and Difficulty Controlling Thoughts Bridge Eating Disorder and Obsessive-Compulsive Disorder Symptoms: A Network Analysis. Journal of Affective Disorders. Volume 283, 2021,p 302-309, DOI: 10.1016/j.jad.2021.01.083.

Highlights

  • Difficulties controlling intrusive thoughts is a common symptom between eating disorders and OCD
  • Perfectionism symptoms bridge eating disorders and OCD
  • Restriction links to checking compulsions and rigidity
  • Binge eating links to hoarding symptoms

Conclusions
The presence of intrusive cognitions and maladaptive perfectionism may contribute to the maintenance of co-occurring ED and OCD symptoms. These findings begin to delineate specific pathways among OCD and ED symptoms, which can be used in the development of interventions to disrupt connections among these disorders.

 

Patients with abrupt early-onset OCD due to PANS tolerate lower doses of antidepressants and antipsychotics

Margo Thienemann, Michelle Park, Avis Chan, Jennifer Frankovich. Patients with abrupt early-onset OCD due to PANS tolerate lower doses of antidepressants and antipsychotics. Journal of Psychiatric Research, Vol 135, 2021, PP 270-278. DOI: 10.1016/j.jpsychires.2021.01.022.

  • More than half of patients with PANS require psychotropic medication.
  • Side effects requiring a therapy change are common.
  • Drug doses at which side effects occur are usually less than recommended.
  • Clinicians should start with lower doses of psychotropics in PANS patients.

“Antidepressants’ most common side effects were anxiety, agitation, aggression, and akathisia. Antipsychotics’ most common side effects were dystonia, aggression, self-injurious behavior, and movement abnormality. Side effects were common at doses lower than the suggested starting doses for these medications. Patients tolerated antidepressants and antipsychotics when doses were low.”

Tetracyclines for COVID-19 Neurological and Neuropsychiatric Manifestations to treat Neuroinflammation

Tetracyclines for COVID-19 Neurological and Neuropsychiatric Manifestations to treat Neuroinflammation

Highlights

  • Neuropsychiatric symptoms were reported during COVID-19.
  • Coronaviruses have neuroinvasive potential and induce a potent neuroinflammatory response.
  • Tetracyclines can counteract neuroinflammation caused by neurotrophic viruses.
  • Tetracyclines interact with viral proteins presenting antiviral effects.
  • Tetracyclines represent a potential treatment for COVID-19 neuropsychiatric symptoms.

Chaves Filho, A.J.M., Gonçalves, F., Mottin, M. et al. Repurposing of Tetracyclines for COVID-19 Neurological and Neuropsychiatric Manifestations: A Valid Option to Control SARS-CoV-2-Associated Neuroinflammation?. J Neuroimmune Pharmacol (2021). https://doi.org/10.1007/s11481-021-09986-3

PANDAS and Persistent Lyme Disease With Neuropsychiatric Symptoms: Treatment, Resolution, and Recovery

Cross Amy, Bouboulis Denis, Shimasaki Craig, Jones Charles Ray. Case Report: PANDAS and Persistent Lyme Disease With Neuropsychiatric Symptoms: Treatment, Resolution, and Recovery. Frontiers in Psychiatry. Vol 12, 2021. DOI:10.3389/fpsyt.2021.505941  

The subject of this case report had a concomitant diagnosis of Lyme borreliosis and PANDAS, both of which are consistent with the neuropsychiatric symptoms she experienced. As evidenced by her recovery and resolution of symptoms, treating both the Lyme infection and streptococcal infection, as well as treating the underlying autoimmune etiology of her neuropsychiatric symptoms resulted in a successful outcome. This case report and treatment history reiterates the complex and challenging nature of infection-triggered autoimmune neuropsychiatric disorders such as PANDAS and PANS and that multiple concomitant infectious agents can frequently be identified in patients suffering from these complex neuropsychiatric disorders. The presence of elevated antineuronal antibodies identified by the Cunningham Panel™ provided an aid in the diagnosis and in directing immunomodulatory treatment. The post-treatment resolution of these autoantibodies provided pathophysiological support for addressing both the infection(s) and the underlying immune system dysfunction which resulted in a positive medical outcome for this patient.

Read more at Moleculera.

Read more at ASPIRE.