Washington House Resolution 4653 Passed Bill Information: HR 4653 – 2021-22- Honoring patients and families affected by PANDAS/PANS. Bill Status Link: Washington.Gov Link Bill Language:...
Bambauer R, Schiel R. Therapeutic Apheresis and Immunosuppression in Immunologic Diseases: A Review and OwnObservations. Clin Immunol Res. 2021; 5(2): 1-36. ISSN 2639-8486
“TA should be reserved for treatment of children and adolescents
who are severely affected by PANDAS. In such patients, it
appears to be safe, well-tolerated, and beneficial treatment
option [130]. Bien et al reported in 2020, besides the first-line
interventions of steroids, IVIG, and TA as second-line treatments
cyclophosphamide or rituximab [131].”
Trifonova, E.A.; Mustafin, Z.S.; Lashin, S.A.; Kochetov, A.V. Abnormal mTOR Activity in Pediatric Autoimmune Neuropsychiatric and MIA-Associated Autism Spectrum Disorders. Int. J. Mol. Sci. 2022, 23, 967. https://doi.org/10.3390/ijms23020967
Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by
the early onset of communication and behavioral problems. ASD is highly heritable; however,
environmental factors also play a considerable role in this disorder. A significant part of both
syndromic and idiopathic autism cases could be attributed to disorders caused by mammalian
target of rapamycin (mTOR)-dependent translation deregulation. This narrative review analyzes both bioinformatic and experimental evidence that connects mTOR signaling to the maternal autoantibody-related (MAR) autism spectrum and autoimmune neuropsychiatric disorders simultaneously. In addition, we reconstruct a network presenting the interactions between the mTOR signaling and eight MAR ASD genes coding for ASD-specific maternal autoantibody target proteins. The research discussed in this review demonstrates novel perspectives and validates the need for a subtyping of ASD on the grounds of pathogenic mechanisms. The utter necessity of designing ELISA-based test panels to identify all antibodies related to autism-like behavior is also considered.
Trunzo, J. J., Statlender, S. M., Leventhal, J. G., Reece, L., Berenbaum, S., & Bransfield, R. (2022). Lyme and tick-borne diseases: A primer for mental health practitioners. Practice...
Before We have four kids; two have PANS. Charlie’s came on like a freight train in the summer of 2010 at age 5. Maddie’s PANDAS was a slower unfolding until...
"Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal infection or PANDAS can also be called post-streptococcal autoimmune basal ganglia...
Register to Watch Virtually Conference videos are available until May. Please note, if you are having problems accessing the conference, please first check your spam folder for an email...
The Seattle Times By Leah Penney, Mental Health Perspectives guest columnist “A few weeks after my 6th birthday, I went to bed one night a happy, healthy child, and I...
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One of the primary symptoms of PANS is Severe Eating Restriction. Over 50% of PANS patients will have non-life threatening eating restrictions but more severe than picky eating. While 17% will...
We know there is no parenting playbook; there certainly isn’t one when you add PANS/PANDAS to the mix. As parents, we are often second-guessing our decisions. So, as you read...