November 21, 2024
Texas PANS PANDAS Updates
On November 13, 2020, The Texas Pediatric Acute-Onset Neuropsychiatric Syndrome Advisory Council met for the first...
Blog
November 15, 2024
Idaho family fights for and wins coverage of treatment for daughter’s rare condition | Opinion
About 90% of the day, she’s bedridden,” he continued, wiping away a tear. “When she’s in a flare, she can’t speak, she can’t walk the majority of the day. She can’t eat or consume...
Dopamine receptor autoantibody signaling in infectious sequelae differentiates movement versus neuropsychiatric disorders
Menendez CM, Zuccolo J, Swedo SE, Reim S, Richmand B, Ben-Pazi H, Kovoor A, Cunningham MW. Dopamine receptor autoantibody signaling in infectious sequelae differentiates movement versus neuropsychiatric disorders. JCI Insight. 2024 Nov 8;9(21):e164762. doi: 10.1172/jci.insight.164762. PMID: 39325550; PMCID: PMC11601707.
October 9, 2024
World PANS PANDAS Awareness Day #LightUp4PANS
Volunteers Needed: We need volunteers to reach out to their municipalities to request that they light up monuments, like the state house, bridges, monuments, etc., be lit up on October 9th,...
October 7, 2024
IOCDF Town Hall on PANS PANDAS
🌟 Join IOCDF for a Special PANS PANDAS Town Hall! 🌟 As part of PANS PANDAS Awareness Week, the IOCDF is hosting an incredible Town Hall featuring three inspiring voices:...
Sammi’s Remarkable Comeback: From Struggle to Strength!
In late November of 2023, we noticed that our daughter, Sammi, had a limp. She had fallen and said her knee hurt. The next week, she began acting very tired...
October 4, 2024
Michigan PANS PANDAS Updates
Current Legislative Action Please visit the MI PANS/PANDAS Alliance to stay updated on how you can take legislative action in Michigan. If you are a Michigan parent of a...
October 2, 2024
The Cost of Inaction –
What is the cost of not treating PANS/ PANDAS promptly & appropriately? We recently sat down with Susan Swedo, MD, to discuss a critical topic: the cost of inaction when...
IVIG response in pediatric acute-onset neuropsychiatric syndrome correlates with reduction in pro-inflammatory monocytes and neuropsychiatric measures
Melamed, Isaac, et al.“IVIG Response in Pediatric Acute-onset Neuropsychiatric Syndrome Correlates with Reduction in Pro-inflammatory Monocytes and Neuropsychiatric Measures.”Frontiers in Immunology, vol. 15, 2024, p. 1383973, https://doi.org/10.3389/fimmu.2024.1383973. Accessed 3 Oct. 2024.
- Study aimed to investigate the pro-inflammatory state in PANS patients before and after IVIG treatment.
- Ten male PANS patients (ages 6–16) received six IVIG infusions over 3 weeks.
- Blood samples and psychiatric assessments were taken before treatment and at follow-up points (4 and 11 weeks post-treatment).
- Myeloid cell activation was analyzed using flow cytometry.* Significant improvement in all psychiatric assessments and parent-reported outcomes (CY-BOCS, YGTSS, and PANS rating scales; all p<0.001).
- Pro-inflammatory monocytes and dendritic cells significantly decreased after IVIG.
- Reduction in pro-inflammatory monocytes was observed both proportionally and in absolute numbers.
October 1, 2024
California PANS PANDAS Updates
California Legislative Action Please follow this page and ASPIRE’s social media for updates – Facebook and Instagram. Please contact CALPANS with questions regarding California legislative...