Blog

Anorexia Nervosa Caused by Polymicrobial Tick-Borne Infections: A Case Study
Kinderlehrer DA. Anorexia Nervosa Caused by Polymicrobial Tick-Borne Infections: A Case Study. Int Med Case Rep J. 2021 May 10;14:279-287. doi: 10.2147/IMCRJ.S311516. PMID: 34007219; PMCID: PMC8121620.

“Conclusion: There is increasing support for the role of infections in the genesis of AN in some patients. The data suggest that autoimmunity is playing a prominent role in the pathogenesis of microbial-induced AN, and that role has been elucidated in children and adolescents with PANS. This is the first documented case of Lyme borreliosis complicated by three co-infections triggering AN. This adds to the existing literature that infections can play a more prominent role in AN. The corollary is that physicians should become aware of this association in the evaluation of patients with AN, as it may provide a treatment option for this serious and sometimes fatal condition. The possibility that tick-borne infections could underlie the diagnosis of AN warrants further study.”

Sharing Hope!
Sharing Hope!

I share our story so you know you are not alone and full healing as possible! My dear daughter 13 is fully healed! I actually came home to this tonight. ...

Read Story

Thank You to ASPIRE’s Volunteers!
April 14, 2021
Thank You to ASPIRE’s Volunteers!

ASPIRE Celebrates Volunteer Appreciation Week! ASPIRE volunteers are the heart of our organization, aiming to improve the lives of those affected by PANS PANDAS. Our different backgrounds and...

Read More


The interference of laboratory tests by immunoglobulin infusion: Problems and solutions

Chen, Renfen & Wei, Xiumei. (2021). The interference of laboratory tests by immunoglobulin infusion: Problems and solutions. Journal of Clinical Images and Medical Case Reports. 2. 10.52768/2766-7820/1047.

  • IVIG infusion can interfere with a wide range of laboratory tests, leading to inaccurate results.
  • The interference stems from the transfer of antibodies and biological agents from donors to patients during IVIG treatment.
  • This interference affects tests in infectious disease serology, autoimmune serology, blood bank, haematology, and biochemistry.
  • After receiving IVIG (intravenous immunoglobulin), testing for pathogens can be influenced by the antibodies present in the IVIG product. These antibodies may show decreased positivity over time, with the antibodies disappearing approximately 2-4 months after the IVIG treatment ceases. It’s crucial to consider the potential impact of IVIG on testing accuracy and consult with healthcare providers for guidance on the timing and methods of pathogen testing post-IVIG treatment.
Clinical guidance for diagnosis and management of suspected Pediatric Acute‐onset Neuropsychiatric Syndrome in the Nordic countries
Pfeiffer HCV, Wickstrom R, Skov L, Sørensen CB, Sandvig I, Gjone IH, Ygberg S, de Visscher C, Idring Nordstrom S, Herner LB, Hesselmark E, Hedderly T, Lim M, Debes NM. Clinical guidance for diagnosis and management of suspected Pediatric Acute-onset Neuropsychiatric Syndrome in the Nordic countries. Acta Paediatr. 2021 Apr 13. doi: 10.1111/apa.15875. Epub ahead of print. PMID: 33848371.

“Consensus was achieved in the collaboration on work‐up and treatment of patients with paediatric acute‐onset neuropsychiatric syndrome, which we hope will improve and homogenise patient care and enable future collaborative research in the field.”

Read article

PDF Link