Antonella Gagliano, Alessandra Carta, Marcello G Tanca & Stefano
Sotgiu (2023) Pediatric Acute-Onset Neuropsychiatric Syndrome: Current Perspectives,
Neuropsychiatric Disease and Treatment, 1221-1250, DOI: 10.2147/NDT.S362202
“The current approach to PANS treatment emphasizes immunomodulation/anti-inflammatory treatments in association with both psychotropic and cognitive-behavioral therapies, while antibiotics are suggested when an active bacterial infection is established. A dimensional view, taking into account the multifactorial origin of psychiatric disorders, should suggest neuro-inflammation as a possible shared substrate of different psychiatric phenotypes. Hence, PANS and PANS-related disorders should be considered as a conceptual framework describing the etiological and phenotypical complexity of many psychiatric disorders.”
Peter J. van Roessel, Giacomo Grassi, Elias N. Aboujaoude, José M. Menchón, Michael Van Ameringen, Carolyn I. Rodríguez. Treatment-resistant OCD: Pharmacotherapies in adults,
Comprehensive Psychiatry, Volume 120, 2023,152352, ISSN 0010-440X, https://doi.org/10.1016/j.comppsych.2022.152352.
Fruchter, Yvette & Gardini, Danielle & Neziroglu, Fugen. (2023). Case study: A child with obsessive-compulsive disorder and cognitive-behavioral therapy. 10.1016/B978-0-323-85757-4.00027-4.
Pediatric autoimmune neuropsychiatric disorders (PANDAS) refer to presence of OCD and/or tic disorder related to group A streptococcal infection (GAS) (Swedo et al., 1998). Hallmark indicators of PANDAS
Liliia Yukhymenko & Sergii Khomenko & Lidiia Iliukha, 2023. “Diagnosis and monitoring of the functioning of the human nervous system,” Chapters of Monographs, in: Modern methods of diagnosing disaeses, chapter 3, pages 69–94, PC TECHNOLOGY CENTER. Handle: RePEc:baq:pcchap:978-617-7319-65-7-ch3. DOI: 10.15587/978-617-7319-65-7.ch3
“Substantiation of the role of the infectious factor in the pathogenesis of the disease in
Genetic deficiency of folate cycle (GDFC) creates the prerequisites for testing antimicrobial treatment strategies based on a personalized assessment of the patient’s microbial profile. According to this Lisa A. Snider et al. performed a double-blind, placebo-controlled, randomized clinical trial of long-term prophylactic therapy with penicillin VK 250 mg twice daily and azithromycin 250 mg twice daily once a week for 1 year in PANDAS. A 96 % reduction in the frequency of exacerbations of streptococcal infection and a 61 % reduction in the number of relapses of PANDAS in patients treated with both penicillin and azithromycin compared with placebo was demonstrated [98]. It is clear that children with neuro-psychiatric manifestations require antiviral, antifungal and antiprotozoal treatment, in addition to antibiotic therapy, if relevant infectious agents are identified, which should be studied in controlledclinical trials.”
Don’t miss this episode of the Autism Mastermind podcast. Malinda Dalton-Cook and Vanessa Surprise bring together autism parents, care providers, and professionals to discuss ways to make our...
Book: Microorganisms and Mental Health
Chapter: Neuropsychiatric Symptoms and Tick-Borne Diseases. Shannon L. Delaney, Lilly A. Murray & Brian A. Fallon. First Online:
In North America, Lyme disease (LD) is primarily caused by the spirochetal bacterium Borrelia burgdorferi, transmitted to humans by Ixodes species tick bites, at an estimated rate of 476,000 patients diagnosed per year. Acute LD often manifests with flu-like symptoms and an expanding rash known as erythema migrans (EM) and less often with neurologic, neuropsychiatric, arthritic, or cardiac features. Most acute cases of Lyme disease are effectively treated with antibiotics, but 10–20% of individuals may experience recurrent or persistent symptoms. This chapter focuses on the neuropsychiatric aspects of Lyme disease, as these are less widely recognized by physicians and often overlooked. Broader education about the potential complexity, severity, and diverse manifestations of tick-borne diseases is needed.
Speaker: Beth Alison Maloney, Esq. Webinar: Protecting Your Child: How Best to Advocate for Sick Children Without Increasing the Risk of Medical Child Abuse Accusations View webinar: Recorded webinar...
Speaker: Sheilah Gauch, LICSW, M.Ed Webinar: Understanding and Managing Caregiver Trauma Associated with PANS PANDAS Register for this webinar: Watch on Demand Abstract In this presentation, we will...
Ellerkamp H, Thienemann M, Tinero J, Shaw R, Dowtin LL, Frankovich J, Borkovi TC. Group Psychotherapy for Parents of Youth with Pediatric Acute-Onset Neuropsychiatric Syndrome. J Clin Psychol Med Settings. 2022 Dec 8. doi: 10.1007/s10880-022-09926-0. Epub ahead of print. PMID: 36480109.
Parents of children with diagnoses of Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) and Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infections (PANDAS) may experience significant psychological distress related to their child’s severe and relapsing illness and challenges with the traumatic nature of its treatment.