Posts by:
Gabriella True

Family Quality of Life When Raising a Child with Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection (PANDAS)
Barbara B. Demchick, Julia Ehler, Shelly Marramar, Alison Mills & Amanda Nuneviller (2019) Family Quality of Life When Raising a Child with Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection (PANDAS), Journal of Occupational Therapy, Schools, & Early Intervention, 12:2, 182-199, DOI: 10.1080/19411243.2019.1592052

“PANDAS is characterized by rapid onset of Obsessive Compulsive Disorder and/or tics following streptococcal infection in a previously healthy child. PANDAS is frequently misdiagnosed and misunderstood, which affects family quality of life (FQOL). A qualitative phenomenological design was used to examine FQOL in six families with a child with PANDAS. Data were collected through an audiotaped semi-structured interview and a phone interview to confirm findings. After rigorous data analysis, five themes emerged: Life Suddenly Turned Upside Down, My Child is Not Crazy, Emotional Distress within the Family, Major Life Alteration, and School Drastically Influences FQOL. Findings suggest that occupational performance and FQOL are severely restricted when a child has PANDAS. Implications for occupational therapy are discussed.”

Autoimmune Diseases and Psychotic Disorders

Rose Jeppesen, Michael Eriksen Benros
Frontiers in Psychiatry

The increasing knowledge on the potential involvement of inflammatory processes in mental disorders and the associations found between autoimmunity and psychotic disorders can help the expanding field of immuno-psychiatry and have impact on the outcome of patients. In the last couple of years, researchers have focused on the role of infections, autoantibodies and other immune components that plays a major role in autoimmune diseases. Potentially this might also be the case for mental disorders.

Bartonella henselae Bloodstream Infection in a Boy With Pediatric Acute-Onset Neuropsychiatric Syndrome
Breitschwerdt EB, Greenberg R, Maggi RG, Mozayeni BR, Lewis A, Bradley JM. Bartonella henselae Bloodstream Infection in a Boy With Pediatric Acute-Onset Neuropsychiatric Syndrome. J Cent Nerv Syst Dis. 2019 Mar 18;11:1179573519832014. doi: 10.1177/1179573519832014. PMID: 30911227; PMCID: PMC6423671.

Methods: Evaluation of a 14-year-old boy with sudden-onset psychotic behavior. Bartonella spp. serology, PCR, DNA sequencing, and blood culture used for assessment. PCR assays for other vector-borne infections performed.

Results:

  • 18 months of psychosis despite multiple hospitalizations, psychiatric medications, and autoimmune encephalitis treatment.
  • Neurobartonellosis diagnosed after cutaneous lesions appeared. Bartonella henselae DNA found in blood despite doxycycline treatment. Negative B. henselae serology.
  • Combination antimicrobial chemotherapy led to symptom improvement, drug cessation, lesion resolution, and return to normal activities.

Conclusions: B. henselae bloodstream infection may contribute to persistent neuropsychiatric symptoms in a subset of PANS patients.

Treating pediatric acute-onset neuropsychiatric syndrome

Elizabeth Heavey; Kathleen Peterson
The Nurse Practitioner-2019

Pediatric acute-onset neuropsychiatric syndrome (PANS) can be caused by infectious and noninfectious triggers. NPs can help children with PANS recover from their symptoms and prevent future recurrences by appropriately screening, recognizing, and diagnosing the clinical presentation of PANS. PANS treatment includes pharmacologic therapies as well as cognitive behavioral therapy.

Neuropsychiatric consequences of childhood group A streptococcal infection: A systematic review of preclinical models

Santiago Mora, Elena Martín-González, Pilar Flores, Margarita Moreno
Brain, Behavior, and Immunity-2019

Preclinical Animal Models are advancing our knowledge of Post-Infectious BGE

  • Preclinical GAS exposure induced behavioural abnormalities in different paradigms
  • Alterations induced by preclinical GAS exposure resemble those by LPS and Poly I:C.
  • Preclinical GAS exposure increase vulnerability to neuropsychiatric disorders.
  • Preclinical GAS exposure is a valid model for studying streptococcal consequences.
Precision medicine: retrospective chart review and data analysis of 200 patients on dapsone combination therapy for chronic Lyme disease/post-treatment Lyme disease syndrome: part 1
Horowitz RI, Freeman PR. Precision medicine: retrospective chart review and data analysis of 200 patients on dapsone combination therapy for chronic Lyme disease/post-treatment Lyme disease syndrome: part 1. Int J Gen Med. 2019 Feb 18;12:101-119. doi: 10.2147/IJGM.S193608. PMID: 30863136; PMCID: PMC6388746.
Diaminodiphenyl sulfone (DDS CT) decreased eight major Lyme symptoms severity and improved treatment outcomes among patients with chronic Lyme disease/PTLDS and associated coinfections.