October 7, 2024
IOCDF Town Hall on PANS PANDAS
🌟 Join IOCDF for a Special PANS PANDAS Town Hall! 🌟 As part of PANS PANDAS Awareness Week, the IOCDF is hosting an incredible Town Hall featuring three inspiring voices:...
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October 2024
Sammi’s Remarkable Comeback: From Struggle to Strength!
In late November of 2023, we noticed that our daughter, Sammi, had a limp. She had fallen and said her knee hurt. The next week, she began acting very tired...
October 2, 2024
The Cost of Inaction –
What is the cost of not treating PANS/ PANDAS promptly & appropriately? We recently sat down with Susan Swedo, MD, to discuss a critical topic: the cost of inaction when...
IVIG response in pediatric acute-onset neuropsychiatric syndrome correlates with reduction in pro-inflammatory monocytes and neuropsychiatric measures
Melamed, Isaac, et al.“IVIG Response in Pediatric Acute-onset Neuropsychiatric Syndrome Correlates with Reduction in Pro-inflammatory Monocytes and Neuropsychiatric Measures.”Frontiers in Immunology, vol. 15, 2024, p. 1383973, https://doi.org/10.3389/fimmu.2024.1383973. Accessed 3 Oct. 2024.
- Study aimed to investigate the pro-inflammatory state in PANS patients before and after IVIG treatment.
- Ten male PANS patients (ages 6–16) received six IVIG infusions over 3 weeks.
- Blood samples and psychiatric assessments were taken before treatment and at follow-up points (4 and 11 weeks post-treatment).
- Myeloid cell activation was analyzed using flow cytometry.* Significant improvement in all psychiatric assessments and parent-reported outcomes (CY-BOCS, YGTSS, and PANS rating scales; all p<0.001).
- Pro-inflammatory monocytes and dendritic cells significantly decreased after IVIG.
- Reduction in pro-inflammatory monocytes was observed both proportionally and in absolute numbers.
October 1, 2024
California PANS PANDAS Updates
California Legislative Action Please follow this page and ASPIRE’s social media for updates – Facebook and Instagram. Please contact CALPANS with questions regarding California legislative...