Monthly Archives:
October 2021

Brain areas involved with obsessive-compulsive disorder present different DNA methylation modulation

de Oliveira, K.C., Camilo, C., Gastaldi, V.D. et al. Brain areas involved with obsessive-compulsive disorder present different DNA methylation modulation. BMC Genom Data 22, 45 (2021). DOI:10.1186/s12863-021-00993-0

  • Confirms involvement of previously associated genes and biological processes in OCD as well as reports differences related to specific brain areas
  • Findings point to a role of cellular communication, inflammatory processes and behavior mediated by DNA methylation in OCD brain tissues.
  • Findings were related to the immune system, reaffirming the current literature findings about its involvement with OCD.
  • Changes in DNA methylation are involved with OCD and further studies are needed to characterize alterations in different paths in each brain area.
Disruptions and Adaptations in Family Functioning: A Study of Families’ Experiences with PANS/PANDAS

Dolce, J.L., LaRusso, M.D. & Abadia-Barrero, C. Disruptions and Adaptations in Family Functioning: A Study of Families’ Experiences with PANS/PANDAS. J Child Fam Stud (2021). DOI:10.1007/s10826-021-02101-3

  • Examined family functioning utilizing online parent forums and nine semi-structured interviews with PANS/PANDAS families.
  • Unpredictability & relapsing-remitting nature of neuropsychiatric symptoms cause significant disruptions to daily life.
  • Financial strain, social isolation, and lack of support from schools and medical institutions transform family functioning.
  • Parents’ frequent use of trauma metaphors to describe experience diverges from literature on other chronic illnesses.