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Tick-Borne

Ecological dynamics of blacklegged ticks, vertebrate hosts, and associated zoonotic pathogens in northeastern forests

LaDeau, Shannon L., KellyOggenfuss, AlexanderSchmidt, SaravananThangamani, and Richard S.Ostfeld. 2025. “Ecological Dynamics of Blacklegged Ticks, Vertebrate Hosts, and Associated Zoonotic Pathogens in Northeastern Forests.” Ecosphere16(12): e70508. https://doi.org/10.1002/ecs2.70508

Researchers tested 2,000+ blacklegged ticks in New York over 9 years

• 38% of ticks carried at least one pathogen capable of infecting humans

• About 10% carried multiple pathogens (co-infection)

• The most common combination was Lyme disease + Babesia microti

• Babesia was found in 21% of ticks, higher than previous estimates

• Bartonella was not detected in the ticks tested at these study sites

Bartonella henselae, Babesia odocoilei and Babesia divergens-like MO-1 infection in the brain of a child with seizures, mycotoxin exposure and suspected Rasmussen’s encephalitis
Breitschwerdt EB, Maggi RG, Robveille C, Kingston E. Bartonella henselae, Babesia odocoilei and Babesia divergens-like MO-1 infection in the brain of a child with seizures, mycotoxin exposure and suspected Rasmussen’s encephalitis. J Cent Nerv Syst Dis. 2025 Mar 12;17:11795735251322456. doi: 10.1177/11795735251322456. PMID: 40083671; PMCID: PMC11905044.
  • Despite cat and suspected tick exposure, Bartonella henselae and Borrelia burgdorferi serology remained negative.
  • Neurodiagnostic testing partially supported Rasmussen’s encephalitis; brain biopsy showed astrogliosis.
  • Bartonella henselae DNA was detected in brain tissue cultures.
  • Babesia odocoilei and Babesia divergens-like MO-1 were confirmed in blood and brain tissue from 2022–2023.
  • Infections, compounded by mycotoxin exposure, created a complex clinical case.
Concurrent Infection of the Human Brain with Multiple Borrelia Species
Golovchenko M, Opelka J, Vancova M, Sehadova H, Kralikova V, Dobias M, Raska M, Krupka M, Sloupenska K, Rudenko N. Concurrent Infection of the Human Brain with Multiple Borrelia Species. Int J Mol Sci. 2023 Nov 29;24(23):16906. doi: 10.3390/ijms242316906. PMID: 38069228; PMCID: PMC10707132.
  • Lyme disease (LD) spirochetes invade tissues, including the brain.
  • Immune evasion tactics: immune suppression, tolerance, antigenic variation, intracellular hiding, biofilms, and persistent forms.
  • Immune-privileged site invasion (e.g., brain) shields spirochetes from immune response and antibiotics.
  • Case study: Spirochetal DNA found in multiple brain regions of a deceased LD patient.
  • Co-infection detected: Borrelia burgdorferi and Borrelia garinii in distinct, non-overlapping brain areas.
  • Atypical spirochete morphology observed in both human and experimentally infected mouse brain tissue.