Fruchter, Yvette & Gardini, Danielle & Neziroglu, Fugen. (2023). Case study: A child with obsessive-compulsive disorder and cognitive-behavioral therapy. 10.1016/B978-0-323-85757-4.00027-4.
Pediatric autoimmune neuropsychiatric disorders (PANDAS) refer to presence of OCD and/or tic disorder related to group A streptococcal infection (GAS) (Swedo et al., 1998). Hallmark indicators of PANDAS
Liliia Yukhymenko & Sergii Khomenko & Lidiia Iliukha, 2023. “Diagnosis and monitoring of the functioning of the human nervous system,” Chapters of Monographs, in: Modern methods of diagnosing disaeses, chapter 3, pages 69–94, PC TECHNOLOGY CENTER. Handle: RePEc:baq:pcchap:978-617-7319-65-7-ch3. DOI: 10.15587/978-617-7319-65-7.ch3
“Substantiation of the role of the infectious factor in the pathogenesis of the disease in
Genetic deficiency of folate cycle (GDFC) creates the prerequisites for testing antimicrobial treatment strategies based on a personalized assessment of the patient’s microbial profile. According to this Lisa A. Snider et al. performed a double-blind, placebo-controlled, randomized clinical trial of long-term prophylactic therapy with penicillin VK 250 mg twice daily and azithromycin 250 mg twice daily once a week for 1 year in PANDAS. A 96 % reduction in the frequency of exacerbations of streptococcal infection and a 61 % reduction in the number of relapses of PANDAS in patients treated with both penicillin and azithromycin compared with placebo was demonstrated [98]. It is clear that children with neuro-psychiatric manifestations require antiviral, antifungal and antiprotozoal treatment, in addition to antibiotic therapy, if relevant infectious agents are identified, which should be studied in controlledclinical trials.”
Don’t miss this episode of the Autism Mastermind podcast. Malinda Dalton-Cook and Vanessa Surprise bring together autism parents, care providers, and professionals to discuss ways to make our...
Book: Microorganisms and Mental Health
Chapter: Neuropsychiatric Symptoms and Tick-Borne Diseases. Shannon L. Delaney, Lilly A. Murray & Brian A. Fallon. First Online:
In North America, Lyme disease (LD) is primarily caused by the spirochetal bacterium Borrelia burgdorferi, transmitted to humans by Ixodes species tick bites, at an estimated rate of 476,000 patients diagnosed per year. Acute LD often manifests with flu-like symptoms and an expanding rash known as erythema migrans (EM) and less often with neurologic, neuropsychiatric, arthritic, or cardiac features. Most acute cases of Lyme disease are effectively treated with antibiotics, but 10–20% of individuals may experience recurrent or persistent symptoms. This chapter focuses on the neuropsychiatric aspects of Lyme disease, as these are less widely recognized by physicians and often overlooked. Broader education about the potential complexity, severity, and diverse manifestations of tick-borne diseases is needed.
Speaker: Beth Alison Maloney, Esq. Webinar: Protecting Your Child: How Best to Advocate for Sick Children Without Increasing the Risk of Medical Child Abuse Accusations View webinar: Recorded webinar...
Speaker: Sheilah Gauch, LICSW, M.Ed Webinar: Understanding and Managing Caregiver Trauma Associated with PANS PANDAS Register for this webinar: Watch on Demand Abstract In this presentation, we will...
Ellerkamp H, Thienemann M, Tinero J, Shaw R, Dowtin LL, Frankovich J, Borkovi TC. Group Psychotherapy for Parents of Youth with Pediatric Acute-Onset Neuropsychiatric Syndrome. J Clin Psychol Med Settings. 2022 Dec 8. doi: 10.1007/s10880-022-09926-0. Epub ahead of print. PMID: 36480109.
Parents of children with diagnoses of Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) and Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infections (PANDAS) may experience significant psychological distress related to their child’s severe and relapsing illness and challenges with the traumatic nature of its treatment.
As a PANDAS kid, I know what a journey it is to have my life interrupted, to be repeatedly misdiagnosed and mistreated, and to ultimately find a solution for my...
Zawilska JB, Kuczyńska K. Psychiatric and neurological complications of long COVID. J Psychiatr Res. 2022 Dec;156:349-360. doi: 10.1016/j.jpsychires.2022.10.045. Epub 2022 Oct 20. PMID: 36326545; PMCID: PMC9582925.
Michael Kandalaft, Edison Leung, Kristin Budd, Jordan Shull, Kendra Anderson,
A case of late onset obsessive-compulsive disorder following an upper respiratory infection,
Psychiatry Research Case Reports, Volume 1, Issue 2, 2022, 100078, ISSN 2773-0212, https://doi.org/10.1016/j.psycr.2022.100078.
This case demonstrates the potential for adult-onset obsessive-compulsive disorder following infection and the value of a complete medical history during psychiatric hospitalization. With the relative rarity of adult-onset obsessive-compulsive disorder, further studies are warranted to determine the treatment and mechanism of pathology.
This scoping review assessed the effect of anti-inflammatory medications in mental disorders. A search in Medline and the Cochrane database focusing on randomised controlled trials and systematic reviews identified 53 primary research articles, conducted in major depression, bipolar disorder, schizophrenia and somatic symptom disorders and related disorders (SSRD). The findings suggest that there is scope to consider the use of anti-inflammatory agents in mental disorders, however, not as a one-size-fits-all solution. Treatment could be especially helpful in subgroups with evidence of baseline inflammation. Anti-inflammatory medications that seem mostly effective in bipolar disorder or major depressive disorder, such as Celecoxib, Pioglitazone and statins, may differ from the ones with indications of effectiveness in schizophrenia, such as Minocycline and Aspirin. This might suggest a different underlying mechanism for treatment success in those two main illness groups. Further studies with larger sample sizes are needed that take levels of inflammation markers into account.
The only relevant agent underlying those neuropsychiatric and somatic complaints was COVID-19, and it was validated with laboratory testing, such as positive IgG titers of SARS-CoV-2 and negative biomarkers for other possible bacterial or viral agents. Generalized epileptic anomaly and a vermian/folial atrophy in the cerebellum were detected in further evaluations. Treatment options consisted of psychotropic agents, antibiotics, antiepileptic, and intravenous immunoglobulin transfusion finely treated the neuropsychiatric symptoms. Clinicians should consider SARS-CoV-2 as a potential agent, when a child presents with abrupt onset, dramatic neuropsychiatric symptoms also consisting of PANS, even in asymptomatic patients or with mild respiratory symptoms.
“As the first treatment option in suspicion of PANS, proper psychotropic treatments and antibiotic agents (amoxicillin-clavulanate, 2 gr/day, for 21 days) were administered to both sisters. The more affected sibling was treated with fluoxetine (40 mg/day), risperidone (1 mg/day), and sodium valproate (20 mg/kg/day) while the less affected sibling with milder symptoms was treated with sertraline (50 mg/day). After one month following these treatment options, IVIG transfusion was required, because of mildly decreased, however, severely continuing psychiatric and somatic complaints. Surprisingly, the somatic complaints, restrictive food intake, OCD symptoms, severe anxiety with hallucinations, depression, and even mild neurologic symptoms were significantly decreased 1 week after the IVIG transfusion; and the patients had weight gain.”