College with PANS/PANDAS: Your Story Matters Starting college can be challenging for any young adult. For students living with PANS/PANDAS, the transition often comes with added layers—managing...
Starting college is an exciting milestone, but for students with PANS/PANDAS, the transition can feel especially overwhelming. Balancing academics, health needs, and independence requires careful...
Missouri Legislative Action is lead by Annie Steil at Missouri PANS/PANDAS Coalition (Facebook and Instagram). Please contact her directly to become involved in legislative advocacy in Missouri. ...
Danieli, M.G.; Buti, E.; Longhi, E.; et al. Advancing Our Understanding of IVIg in Pediatric Acute-Onset Neuropsychiatric Syndrome. Journal of Mosaic of Autoimmunity 2025, 1 (2), 5. doi.org/10.53941/jmai.2025.100012
Reviews intravenous immunoglobulin (IVIg) as a pooled IgG product with broad immunomodulatory and anti-inflammatory effects.
Describes mechanisms including modulation of Fcγ receptors, inhibition of complement activation, cytokine regulation, and control of pro-inflammatory immune cells.
Explains that IVIg can influence both innate and adaptive immune systems, including via epigenetic mechanisms.
Summarizes evidence indicating IVIg can attenuate neuropsychiatric symptoms and restore immune balance in children with PANS.
Notes variability in randomized trial outcomes but highlights converging clinical and mechanistic support for IVIg in selected patients.
Emphasizes the need for biomarker-guided studies to identify responders and optimize treatment strategies.
