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Eating Disorder

Association of Exposure to Infections in Childhood With Risk of Eating Disorders in Adolescent Girls

Lauren Breithaupt, Ole Köhler-Forsberg, Janne Tidselbak Larsen
JAMA Psychiatry-2019

Findings: In a Danish population-based cohort study of 525 643 adolescent girls, a prior infection in childhood was associated with an increased risk of later anorexia nervosa, bulimia nervosa, and eating disorder not otherwise specified.
Meaning: The findings suggest that prior exposure to infections and treatment with anti-infective agents are associated with the development of eating disorders, supporting an emerging immunologic hypothesis.

PANDAS and anorexia nervosa-a spotters’ guide: Suggestions for medical assessment
Vincenzi B, O’Toole J, Lask B. PANDAS and anorexia nervosa–a spotters’ guide: suggestions for medical assessment. Eur Eat Disord Rev. 2010 Mar;18(2):116-23. doi: 10.1002/erv.977. PMID: 20148396.
Conclusion: Given the current state of knowledge, diagnosingPANDAS is extraordinarily difficult. However, extrapolating from knowledge aboutSydenham’s choreaandPANDAS–OCD and PANDAS–tics/TS, a heightened index of suspicion for the existence of an auto-immune reaction in the brain response to environmental infectious agents culminating in ‘anorexia nervosa’ should be maintained.