David S. Younger, Phyllis A. Mast, and Denis A. Bouboulis
Journal of Neurology and Neurosurgery-2016
Children with PANDAS who had baseline low IgA, IgG or IgG subclass levels were more likely than others to achieve 100 % improvement after IVIg therapy at 12 months follow-up.
One Heart, One Mind gives families, as well as health professionals, a fresh look at how practical solutions to autism can be discovered in a book that offers exactly what parents are seeking:...
Çelik, Taş, Tahiroğlu, Avci , Yüksel, Çam
Noro Psikiyatr Ars-2017
PDF
This study supports the hypothesis that an association between vitamin D metabolism and PANDAS-related OCD exists. We suggest that biochemical parameters predicting metabolic bone diseases are more common in PANDAS patients.
Y. Kulkarni, R. Warkari, “Pandas: A Rare Case Report”, International Journal of Science and Research (IJSR), Volume 5 Issue 2, February 2016, pp. 148-149, https://www.ijsr.net/get_abstract.php?paper_id=NOV161061
Abstract: PANDAS, also labelled as PANS, is a pediatric autoimmune neuropsychiatric disorder due to streptococcal infection. Although it affects 1 in 1000 children, cases reported in Indian context are relatively few because of lack of awareness about the syndrome amongst clinicians. We report here a case of a 13 years old male from a rural area presenting to us with an acute onset of repetitive behavior following a febrile illness 2 months prior. Investigations confirmed rheumatic valvular heart disease. A diagnosis of PANDAS was made and treatment was started. The patient responded to treatment and gained symptomatic relief. Timely intervention
and high index of suspicion towards a pediatric febrile illness can help to reduce the morbidity associated with this neuropsychiatric
disorder.
Graziella Orefici, PhD, Francesco Cardona, MD, Carol J. Cox, PhD, and Madeleine W. Cunningham, PhD.
From the Book: Streptococcus pyogenes Basic Biology to Clinical Manifestations – University of Oklahoma Health Sciences Center-2016
PDF
The inclusion of a chapter on pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (or PANDAS) is essential to provide a history of the disease and provide current information about its association with Streptococcus pyogenes (group A streptococci), tics, obsessive compulsive disorder (OCD) and its relationship to Sydenham chorea (SC), which is the neurologic manifestation of acute rheumatic fever.
Jon E. Grant, JD, MD, MPH; Samuel R. Chamberlain, MD, PhD; Sarah A. Redden, BA; Eric W. Leppink, BA; Brian L. Odlaug, PhD; Suck Won Kim, MD
JAMA Psychiatry-2016
This investigation suggests that N-acetylcysteine appears to be effective and well tolerated in the acute treatment of SPD. As effective treatments for skin picking emerge, it becomes increasingly important that physicians and other mental health care professionals screen for the disorder to provide timely treatment.
Thamotharampillai Dileepan, Erica D. Smith, Daniel Knowland, Martin Hsu, Maryann Platt, Peter Bittner-Eddy, Brenda Cohen, Peter Southern, Elizabeth Latimer, Earl Harley Dritan Agalliu. and P. Patrick Cleary
Journal of Clinical Investigation-2015
PDF
Our results establish what we believe to be evidence of a novel crosstalk between the CNS and cellular immunity to infections, which may contribute to understanding the pathogenesis of many other CNS autoimmune diseases. Flare-ups associated with several chronic autoimmune conditions may be produced by the expansion of Th17 cells and the activation of cytokines induced by relatively common bacterial or viral infections. Aberrant cytokine expression could then disrupt the BBB to permit preexisting circulating autoantibodies to enter the brain, engage neural targets, and trigger the sudden onset of clinical symptoms.
Michelle M. Papachrisanthou, DNP, CPNP-PC, Renée L. Davis, DNP, CPNP-PC
Journal of Nurse Practitioners-2015
Molly McClelland, PhD, RN, Mary-Margaret Crombez, MEd, Catherine Crombez, BSc, Catherine Wenz, MSN, RN, FNP-BC, Margaret Lisius, MSW, Amanda Mattia, BSN, RN, Suzana Marku, BSN, RN
JPED-2015
PDF
Using paradigmatic analysis of transcribed interviews, three themes were identified: fear, frustration, and not being heard.
Antoine Louveau, Igor Smirnov, Timothy J. Keyes, Jacob D. Eccles, Sherin J. Rouhani, J. David Peske, Noel C. Derecki, David Castle, James W. Mandell, Kevin S. Lee, Tajie H. Harris & Jonathan Kipnis
Nature-2015
The research findings reported in this study challenge the dogmas regarding the immune privilege status of the central nervous system (CNS) and its isolation from the immune system by the blood-brain barrier. Functional meningeal lymphatic vessels capable of carrying immune cells and interstitial fluids from the CNS are identified and characterized. Findings provide novel understanding on how autoimmune encephalopathies, like PANS/ PANDAS, can develop when these unique lymphatic vessels malfunction. Structural and functional features of central nervous system lymphatic vessels.
Walls A, Cubangbang M, Wang H, Raiji M, Knight J, Steehler M, Latimer E, Harley EH Jr.
Otolaryngol Head Neck Surg.-2015
Patients diagnosed with PANDAS appear to maintain significantly different concentrations of cytokines when compared with patients afflicted by chronic group A beta hemolytic streptococcus infections and obstructive sleep apnea. As a result, one could potentially use the described characterization of immunologic markers as a basis for future mechanistic and epidemiological studies.